掌部银屑病、慢性手部湿疹和角化过度型手部湿疹之间角蛋白和兜甲蛋白的免疫组化鉴别
Immunohistochemical differentiation of keratins and involucrin between palmar psoriasis, chronic hand eczema and hyperkeratotic hand eczema.
作者信息
Baek Eun Joo, Jung Da Yeon, Seung Na Reu, Jang Ye Ji, Park Eun Joo, Kim Kwang Ho
机构信息
Department of Dermatology, College of Medicine, Hallym University, Anyang, Korea.
Seoul Hong Skin Clinic, Seoul, Korea.
出版信息
Contact Dermatitis. 2024 Apr;90(4):385-393. doi: 10.1111/cod.14499. Epub 2024 Jan 11.
BACKGROUND
Common hyperkeratotic palmar skin lesions include chronic hand eczema (CHE), hyperkeratotic hand eczema (HHE), palmar psoriasis (PP). However, clinically differentiating these disorders is often challenging.
OBJECTIVES
To compare the expressions of keratin (K) 5, K9, K14 and involucrin in palmar hyperkeratotic lesions (HHE, CHE and PP).
MATERIALS AND METHODS
Immunohistochemical staining was performed on skin biopsy specimens obtained from the palms of patients clinically diagnosed with CHE, HHE and PP (n = 21, 24 and 18, respectively).
RESULTS
K5 and K14 expression levels were higher in the spinous and granular layers of PP and HHE compared to CHE. Involucrin was expressed in the basal layer of PP and HHE but not in CHE. K9 expression was decreased in PP and HHE compared to CHE.
CONCLUSION
Keratin and involucrin expression in the epidermis are markers of keratinocyte differentiation. Expression levels of keratin and involucrin were similar between the HHE and PP groups, suggesting that HHE shares pathogenesis with PP rather than CHE.
背景
常见的掌部角化过度性皮肤病变包括慢性手部湿疹（CHE）、角化过度性手部湿疹（HHE）、掌部银屑病（PP）。然而，临床上区分这些疾病往往具有挑战性。
目的
比较角蛋白（K）5、K9、K14和内披蛋白在掌部角化过度性病变（HHE、CHE和PP）中的表达。
材料与方法
对临床诊断为CHE、HHE和PP的患者（分别为21例、24例和18例）手掌皮肤活检标本进行免疫组织化学染色。
结果
与CHE相比，PP和HHE的棘层和颗粒层中K5和K14表达水平更高。PP和HHE的基底层表达内披蛋白，而CHE中不表达。与CHE相比，PP和HHE中K9表达降低。
结论
表皮中的角蛋白和内披蛋白表达是角质形成细胞分化的标志物。HHE和PP组之间角蛋白和内披蛋白的表达水平相似，提示HHE与PP具有共同的发病机制，而非CHE。
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