Department of Pathology & Immunology, Washington University, St Louis, MO.
Lab Med. 2024 Jul 3;55(4):464-470. doi: 10.1093/labmed/lmad112.
A1C ≥6.0% is associated with increased risk of adverse outcomes in pregnant diabetic patients. A1C testing is recommended by the American Diabetes Association as a secondary measure of glycemic control in pregnant patients.
To determine the utility of A1C point-of-care testing (POCT) during pregnancy to facilitate rapid counseling and diabetes care, particularly in relatively low-income transient patient populations.
We performed a single-center, retrospective analysis of patients presenting to an outpatient obstetrics office with routine, in-laboratory A1C testing, before and after the implementation of POCT for A1C (n = 70 and n = 75, respectively). Demographics, results, physician referral to a nutritionist, counseling, and outcomes were retrieved from patient electronic medical records.
In total, 9% and 23% of the in-laboratory and POCT groups, respectively, were referred for nutrition services (P = .02). Of these, 22% of the in-laboratory group and 42% of the POCT group received immediate counseling (P < .01). An inverse correlation was observed between A1C level at study entry and gestational weeks at delivery, with a Pearson r value of -0.39 (-0.58 to -0.16) for the in-laboratory group and -0.38 (-0.57 to -0.14) for the POCT group. No statistically significant difference in pregnancy outcomes was observed.
Implementation of A1C POCT was associated with immediate counseling and management of the health of pregnant patients, but was not associated with improved outcomes, in a low-resource patient population.
A1C≥6.0%与妊娠糖尿病患者不良结局风险增加相关。美国糖尿病协会建议在妊娠患者中,将 A1C 检测作为血糖控制的次要指标。
确定 A1C 即时检测(POCT)在妊娠期间的应用效用,以促进快速咨询和糖尿病管理,尤其是在相对低收入的临时患者群体中。
我们对在门诊妇产科就诊的患者进行了一项单中心、回顾性分析,这些患者在实施 A1C POCT 前后(分别为 n=70 和 n=75)均进行了常规实验室 A1C 检测。从患者的电子病历中检索了人口统计学数据、检测结果、医生是否将患者转介给营养师、咨询情况和结局。
在实验室和 POCT 组中,分别有 9%和 23%的患者被转介到营养科(P=0.02)。其中,实验室组的 22%和 POCT 组的 42%患者接受了即时咨询(P<0.01)。研究开始时的 A1C 水平与分娩时的妊娠周数呈负相关,实验室组的 Pearson r 值为-0.39(-0.58 至-0.16),POCT 组为-0.38(-0.57 至-0.14)。两组的妊娠结局无统计学差异。
在资源有限的患者群体中,实施 A1C POCT 与妊娠患者的即时咨询和健康管理相关,但与改善结局无关。