Noland-Gerbec E A, Pfohl R J, Taylor D H, Bull R J
Neurotoxicology. 1986 Fall;7(3):157-64.
Trichloroethylene (TCE) is a widespread contaminant of drinking water sources. The effects of TCE on 2-deoxyglucose uptake by brain tissue were examined in pups from rat dams exposed to TCE in their drinking water. The pups were exposed throughout gestation and lactation. Deoxyglucose uptake in the cerebellum, hippocampus and whole brain of the pups during the first 21 days of life was measured using a modification of the 2-deoxy-D-glucose (2-DG) technique. We determined that TCE at a nominal concentration of 312 mg/l significantly depressed 2-DG uptake in the whole brains and cerebella of 7- to 21-day old pups. 2-DG uptake was also lower in the hippocampus of exposed pups at 7, 11 and 16 days, but returned to control levels by 21 days. No overt toxicity, such as lower body or brain weight, was observed at this exposure level. This decrease in 2-DG uptake reflects a decrease in glucose uptake and/or metabolism in the brains of animals exposed to TCE.
三氯乙烯（TCE）是一种广泛存在的饮用水源污染物。在饮用含TCE水的大鼠母鼠所产幼崽中，研究了TCE对脑组织摄取2-脱氧葡萄糖的影响。幼崽在整个妊娠期和哺乳期都暴露于TCE。采用改良的2-脱氧-D-葡萄糖（2-DG）技术，测定了出生后21天内幼崽小脑、海马和全脑的脱氧葡萄糖摄取量。我们发现，名义浓度为312 mg/l的TCE显著降低了7至21日龄幼崽全脑和小脑的2-DG摄取量。在7、11和16日龄时，暴露幼崽海马体中的2-DG摄取量也较低，但在21日龄时恢复到对照水平。在该暴露水平下，未观察到明显的毒性，如体重减轻或脑重量减轻。2-DG摄取量的下降反映了暴露于TCE的动物大脑中葡萄糖摄取和/或代谢的减少。
