对参与血小板活性和心血管疾病的十种主要血小板受体的全面综述。
A comprehensive review of the ten main platelet receptors involved in platelet activity and cardiovascular disease.
作者信息
Hashemzadeh Mehrnoosh, Haseefa Fathima, Peyton Lee, Shadmehr Mehrdad, Niyas Abdullah M, Patel Aamir, Krdi Ghena, Movahed Mohammad Reza
机构信息
University of Arizona College of Medicine Phoenix, AZ, USA.
Pima College Tucson, AZ, USA.
出版信息
Am J Blood Res. 2023 Dec 25;13(6):168-188. doi: 10.62347/NHUV4765. eCollection 2023.
Cardiovascular disease (CVD) is a major cause of death worldwide. Although there are many variables that contribute to the development of this disease, it is predominantly the activity of platelets that provides the mechanisms by which this disease prevails. While there are numerous platelet receptors expressed on the surface of platelets, it is largely the consensus that there are 10 main platelet receptors that contribute to a majority of platelet function. Understanding these key platelet receptors is vitally important for patients suffering from myocardial infarction, CVD, and many other diseases that arise due to overactivation or mutations of these receptors. The goal of this manuscript is to review the main platelet receptors that contribute most to platelet activity.
心血管疾病（CVD）是全球主要的死亡原因。尽管有许多因素促成这种疾病的发展，但主要是血小板的活性提供了该疾病流行的机制。虽然血小板表面表达有众多血小板受体，但普遍认为有10种主要的血小板受体促成了大部分血小板功能。对于患有心肌梗死、心血管疾病以及由于这些受体过度激活或突变而引发的许多其他疾病的患者来说，了解这些关键的血小板受体至关重要。本手稿的目的是综述对血小板活性贡献最大的主要血小板受体。
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