认知正常的老年成年人非快速眼动睡眠 delta 子带中光谱功率的多模态神经影像学相关性。
Multimodal neuroimaging correlates of spectral power in NREM sleep delta sub-bands in cognitively unimpaired older adults.
机构信息
Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders," NeuroPresage Team, Institut Blood and Brain @ Caen-Normandie, GIP Cyceron, 14000 Caen, France.
Normandie Univ, UNICAEN, PSL Université, EPHE, INSERM, U1077, CHU de Caen, GIP Cyceron, NIMH, 14000 Caen, France.
出版信息
Sleep. 2024 Apr 12;47(4). doi: 10.1093/sleep/zsae012.
STUDY OBJECTIVES
In aging, reduced delta power (0.5-4 Hz) during N2 and N3 sleep has been associated with gray matter (GM) atrophy and hypometabolism within frontal regions. Some studies have also reported associations between N2 and N3 sleep delta power in specific sub-bands and amyloid pathology. Our objective was to better understand the relationships between spectral power in delta sub-bands during N2-N3 sleep and brain integrity using multimodal neuroimaging.
METHODS
In-home polysomnography was performed in 127 cognitively unimpaired older adults (mean age ± SD: 69.0 ± 3.8 years). N2-N3 sleep EEG power was calculated in delta (0.5-4 Hz), slow delta (0.5-1 Hz), and fast delta (1-4 Hz) frequency bands. Participants also underwent magnetic resonance imaging and Florbetapir-PET (early and late acquisitions) scans to assess GM volume, brain perfusion, and amyloid burden. Amyloid accumulation over ~21 months was also quantified.
RESULTS
Higher delta power was associated with higher GM volume mainly in fronto-cingular regions. Specifically, slow delta power was positively correlated with GM volume and perfusion in these regions, while the inverse association was observed with fast delta power. Delta power was neither associated with amyloid burden at baseline nor its accumulation over time, whatever the frequency band considered.
CONCLUSIONS
Our results show that slow delta is particularly associated with preserved brain structure, and highlight the importance of analyzing delta power sub-bands to better understand the associations between delta power and brain integrity. Further longitudinal investigations with long follow-ups are needed to disentangle the associations among sleep, amyloid pathology, and dementia risk in older populations.
CLINICAL TRIAL INFORMATION
Name: Study in Cognitively Intact Seniors Aiming to Assess the Effects of Meditation Training (Age-Well). URL: https://clinicaltrials.gov/ct2/show/NCT02977819?term=Age-Well&draw=2&rank=1. See STROBE_statement_AGEWELL in supplemental materials.
REGISTRATION
EudraCT: 2016-002441-36; IDRCB: 2016-A01767-44; ClinicalTrials.gov Identifier: NCT02977819.
研究目的
在衰老过程中，N2 和 N3 睡眠期间的δ功率降低（0.5-4 Hz）与额区的灰质（GM）萎缩和代谢降低有关。一些研究还报告了 N2 和 N3 睡眠δ功率在特定子频带与淀粉样蛋白病理学之间的关联。我们的目的是使用多模态神经影像学更好地理解 N2-N3 睡眠期间δ子频带的光谱功率与大脑完整性之间的关系。
方法
对 127 名认知正常的老年人（平均年龄±标准差：69.0±3.8 岁）进行家庭多导睡眠图检查。在 δ（0.5-4 Hz）、慢 δ（0.5-1 Hz）和快 δ（1-4 Hz）频带中计算 N2-N3 睡眠 EEG 功率。参与者还接受了磁共振成像和 Florbetapir-PET（早期和晚期采集）扫描，以评估 GM 体积、脑灌注和淀粉样蛋白负荷。还量化了大约 21 个月的淀粉样蛋白积累。
结果
较高的 δ 功率与额顶叶区域的 GM 体积较高有关。具体来说，慢 δ 功率与这些区域的 GM 体积和灌注呈正相关，而快 δ 功率则呈负相关。无论考虑哪个频带，δ 功率均与基线时的淀粉样蛋白负荷或随时间的积累无关。
结论
我们的结果表明，慢 δ 与大脑结构的保存特别相关，并强调了分析 δ 功率子频带来更好地理解 δ 功率与大脑完整性之间关系的重要性。需要进行具有长期随访的进一步纵向研究，以厘清老年人睡眠、淀粉样蛋白病理学和痴呆风险之间的关联。
临床试验信息
名称：评估冥想训练对认知健康老年人影响的研究（Age-Well）。网址：https://clinicaltrials.gov/ct2/show/NCT02977819?term=Age-Well&draw=2&rank=1。见补充材料中的 STROBE_statement_AGEWELL。
注册
EudraCT：2016-002441-36；IDRCB：2016-A01767-44；ClinicalTrials.gov 标识符：NCT02977819。
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