Center for Immunity and Inflammation, Department of Pathology, Immunology, and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, NJ.
J Immunol. 2024 Feb 1;212(3):361-368. doi: 10.4049/jimmunol.2300399.
Tissue-resident memory T (Trm) cells are a subset of T cells maintained throughout life within nonlymphoid tissues without significant contribution from circulating memory T cells. CD8+ Trm cells contribute to both tissue surveillance and direct elimination of pathogens through a variety of mechanisms. Reactivation of these Trm cells during infection drives systematic changes within the tissue, including altering the state of the epithelium, activating local immune cells, and contributing to the permissiveness of the tissue for circulating immune cell entry. Trm cells can be further classified by their functional outputs, which can be either subset- or tissue-specific, and include proliferation, tissue egress, and modulation of tissue physiology. These functional outputs of Trm cells are linked to the heterogeneity and plasticity of this population, and uncovering the unique responses of different Trm cell subsets and their role in immunity will allow us to modulate Trm cell responses for optimal control of disease.
组织驻留记忆 T（Trm）细胞是 T 细胞的一个亚群，它们在非淋巴组织中终生存在，而循环记忆 T 细胞对其贡献不大。CD8+ Trm 细胞通过多种机制有助于组织监测和直接消除病原体。在感染过程中这些 Trm 细胞的再激活会导致组织内的系统性变化，包括改变上皮状态、激活局部免疫细胞，并有助于组织对循环免疫细胞进入的允许性。Trm 细胞还可以根据其功能输出进一步分类，这些功能输出可以是亚群特异性或组织特异性的，包括增殖、组织迁出和调节组织生理学。这些 Trm 细胞的功能输出与该群体的异质性和可塑性有关，揭示不同 Trm 细胞亚群的独特反应及其在免疫中的作用将使我们能够调节 Trm 细胞的反应，以实现对疾病的最佳控制。
