产前皮质激素暴露与 23 至 29 孕周出生婴儿出生后生长的关系。
The association between antenatal corticosteroids exposure and postnatal growth in infants born between 23 and 29 weeks of gestation.
机构信息
Department of Neonatology, Kaiser Permanente Riverside Medical Center, Riverside, CA, USA.
Southern California Permanente Medical Group, Pasadena, CA, USA.
出版信息
J Perinatol. 2024 Apr;44(4):561-567. doi: 10.1038/s41372-024-01871-0. Epub 2024 Jan 16.
OBJECTIVE
To assess the association between antenatal corticosteroids exposure and postnatal growth in infants born at 23-29 weeks' gestation.
STUDY DESIGN
This retrospective study used data from the Pediatrix Clinical Data Warehouse. Maternal-infant dyads from 2018 to 2020 were included. Inverse propensity weighting (IPW) was applied to balance pre-treatment confounders. Primary outcomes included postnatal weight, length, and head circumference growth trajectory percentiles.
RESULT
The unadjusted cohort consisted of 11,912 dyads. After IPW adjustment, there were 23,231 dyads. Exposed infants showed higher postnatal trajectory percentiles for weight (by 3.4%), length (by 1.8%), and head circumference (by 2.5%) when compared to non-exposed infants. The positive association between antenatal corticosteroids and postnatal growth was only observed in infants not exposed to preeclampsia/eclampsia/HELLP syndrome or without fetal growth restriction.
CONCLUSION
Antenatal corticosteroids exposure is associated with better postnatal growth. The study is limited by its retrospective nature.
目的
评估在 23-29 孕周出生的婴儿中，产前皮质激素暴露与出生后生长的关系。
研究设计
这是一项回顾性研究，使用了 Pediatrix 临床数据仓库的数据。纳入了 2018 年至 2020 年的母婴对子。采用逆概率加权（Inverse Propensity Weighting，IPW）来平衡治疗前的混杂因素。主要结局包括出生后体重、身长和头围的生长轨迹百分位数。
结果
未调整的队列包括 11912 对母婴。经过 IPW 调整后，有 23231 对母婴。与未暴露于产前皮质激素的婴儿相比，暴露于产前皮质激素的婴儿在体重（增加 3.4%）、身长（增加 1.8%）和头围（增加 2.5%）的出生后生长轨迹百分位数更高。产前皮质激素与出生后生长之间的正相关关系仅在未暴露于子痫前期/子痫/HELLP 综合征或无胎儿生长受限的婴儿中观察到。
结论
产前皮质激素暴露与更好的出生后生长有关。该研究受到其回顾性的限制。
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