Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Eur J Clin Invest. 2024 May;54(5):e14153. doi: 10.1111/eci.14153. Epub 2024 Jan 17.
Mendelian randomization analysis was applied to elucidate the causal relationship between the basal metabolic rate (BMR) and common cardiovascular diseases.
We choose BMR as exposure. BMR is the metabolic rate of the body when the basic physiological activities (blood circulation, breathing and constant body temperature) are maintained. The normal BMR is 1507 kcal/day for men and 1276 kcal/day for women. The dataset was drawn from the public GWAS dataset (GWAS ID: ukb-a-268), collected and analysed by UK biobank, containing 331,307 European males and females. SNPs independently and strongly associated with BMR were used as instrumental variables in the inverse variance weighted analysis. MR-Egger, weighted median, MR pleiotropy residual sum, and outlier methods were also performed, and the sensitivity was evaluated using horizontal pleiotropy and heterogeneity analyses to ensure the stability of the results.
An increased BMR is associated with a higher risk of cardiomyopathy (odds ratio [OR] = 2.00, 95% confidence interval [CI], 1.57-2.54, p = 1.87 × 10), heart failure (OR = 1.39, 95% CI, 1.27-2.51, p = 8.1 × 10), and valvular heart disease (OR = 1.18, 95% CI, 1.10-1.27, p = .00001). However, there was no clear association between BMR and the subtypes of other cardiovascular diseases, such as coronary disease (OR = .96, 95% CI, .85-1.08, p = .48651) and atrial fibrillation (AF) (OR = 1.85, 95% CI, 1.70-2.02, p = 6.28 × 10).
Our study reveals a possible causal effect of BMR on the risk of cardiomyopathy, heart failure and valvular disease, but not for coronary disease and AF.
孟德尔随机化分析被应用于阐明基础代谢率（BMR）与常见心血管疾病之间的因果关系。
我们选择 BMR 作为暴露因素。BMR 是指身体在维持基本生理活动（血液循环、呼吸和恒定体温）时的代谢率。正常男性的 BMR 为 1507 千卡/天，正常女性的 BMR 为 1276 千卡/天。该数据集取自公共 GWAS 数据集（GWAS ID：ukb-a-268），由英国生物银行收集和分析，包含 331307 名欧洲男性和女性。与 BMR 独立且强烈相关的 SNP 被用作逆方差加权分析中的工具变量。还进行了 MR-Egger、加权中位数、MR 多效性残差和异常值方法分析，并通过水平多效性和异质性分析评估了敏感性，以确保结果的稳定性。
BMR 升高与心肌病（比值比 [OR] = 2.00，95%置信区间 [CI]，1.57-2.54，p = 1.87 × 10）、心力衰竭（OR = 1.39，95%CI，1.27-2.51，p = 8.1 × 10）和瓣膜性心脏病（OR = 1.18，95%CI，1.10-1.27，p = 0.00001）的风险增加相关。然而，BMR 与其他心血管疾病的亚型之间没有明显的关联，例如冠心病（OR = 0.96，95%CI，0.85-1.08，p = 0.48651）和心房颤动（AF）（OR = 1.85，95%CI，1.70-2.02，p = 6.28 × 10）。
我们的研究揭示了 BMR 对心肌病、心力衰竭和瓣膜性疾病风险的可能因果影响，但对冠心病和 AF 没有影响。
