针对组织特异性的TRIM
TRIM for Tissue Specificity.
作者信息
Hartmann Marcus D
机构信息
Department of Protein Evolution, Max Planck Institute for Biology Tübingen, 72076 Tübingen, Germany.
Interfaculty Institute of Biochemistry, University of Tübingen, 72076 Tübingen, Germany.
出版信息
ACS Med Chem Lett. 2023 Dec 26;15(1):4-5. doi: 10.1021/acsmedchemlett.3c00504. eCollection 2024 Jan 11.
Abstract
Tissue-specific manipulation of proteins is a long-standing objective in the field of targeted protein degradation, but still a distant prospect. Currently, the most successfully employed E3 ubiquitin ligases belong to the most ubiquitously expressed representatives. Unlocking of the TRIM58 ligase might represent a promising step toward tissue-specific PROTACs and molecular glue degraders.
摘要
蛋白质的组织特异性操纵是靶向蛋白质降解领域长期以来的目标，但仍遥不可及。目前，最成功应用的E3泛素连接酶属于表达最广泛的代表。解锁TRIM58连接酶可能是迈向组织特异性PROTAC和分子胶降解剂的有希望的一步。
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