Institute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway
Center for treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Health Services Research and Innovation Unit, Diakonhjemmet Hospital, Oslo, Norway.
RMD Open. 2024 Jan 18;10(1):e003440. doi: 10.1136/rmdopen-2023-003440.
To assess the effect of high-intensity interval training (HIIT) delivered in physiotherapy primary care on the primary outcome of cardiorespiratory fitness (CRF) in patients with inflammatory arthritis (IA). Additionally, to explore the effects of HIIT on secondary outcomes, including cardiovascular disease (CVD) risk factors and disease activity.
Single-blinded randomised controlled trial with 60 patients randomly assigned to either a control group receiving usual care or an exercise group receiving usual care and 12 weeks of individualised HIIT at 90%-95% peak heart rate. Outcomes were assessed at baseline, 3 months and 6 months post baseline and included CRF measured as peak oxygen uptake (VO), classic CVD risk factors, disease activity, anthropometry and patient-reported physical activity, pain, fatigue, disease impact and exercise beliefs and self-efficacy.
Intention-to-treat analysis demonstrated a significant between-group difference in VO at 3 months (2.5 mL/kg/min, 95% CI 0.9 to 4.0) and 6 months (2.6 mL/kg/min, 95% CI 0.8 to 4.3) in favour of the exercise group. A beneficial change in self-reported physical activity in favour of the exercise group was observed at 3 and 6 months. The HIIT intervention was well-tolerated with minimal adverse events and no apparent impact on disease activity. Differences in secondary outcomes related to CVD risk factors, disease impact, pain, fatigue and exercise beliefs and self-efficacy were generally small and non-significant.
After 12 weeks of supervised HIIT delivered in physiotherapy primary care, patients with IA demonstrated a favourable improvement in CRF, with sustained effects at 6-month follow-up.
NCT04922840.
评估在理疗初级保健中进行高强度间歇训练（HIIT）对炎症性关节炎（IA）患者心肺功能（CRF）主要结局的影响。此外，还探讨了 HIIT 对二级结局的影响，包括心血管疾病（CVD）危险因素和疾病活动。
单盲随机对照试验，将 60 名患者随机分为对照组（接受常规护理）和运动组（接受常规护理和 12 周个体化的 90%-95%峰值心率 HIIT）。在基线、3 个月和 6 个月后评估结局，包括 CRF 测量的峰值摄氧量（VO）、经典 CVD 危险因素、疾病活动、人体测量和患者报告的体力活动、疼痛、疲劳、疾病影响和锻炼信念和自我效能。
意向治疗分析表明，在 3 个月（2.5 mL/kg/min，95%CI 0.9 至 4.0）和 6 个月（2.6 mL/kg/min，95%CI 0.8 至 4.3）时，运动组 VO 存在显著的组间差异。在 3 个月和 6 个月时，观察到患者自我报告的体力活动有有益的改善，有利于运动组。HIIT 干预耐受良好，不良反应极小，对疾病活动没有明显影响。与 CVD 危险因素、疾病影响、疼痛、疲劳和锻炼信念和自我效能相关的次要结局差异通常较小且无统计学意义。
在理疗初级保健中进行 12 周的监督 HIIT 后，IA 患者的 CRF 表现出有利的改善，在 6 个月的随访中持续有效。
NCT04922840。
