Nuclear and Chemical Sciences Division, Physical and Life Sciences, Lawrence Livermore National Laboratory, Livermore, CA, USA.
Biosciences and Biotechnology Division, Physical and Life Sciences, Lawrence Livermore National Laboratory, Livermore, CA, USA.
Sci Rep. 2024 Jan 19;14(1):1762. doi: 10.1038/s41598-024-52082-8.
The development of new antibiotics has stalled, and novel strategies are needed as we enter the age of antibiotic resistance. Certain naturally occurring clays have been shown to be effective in killing antibiotic resistant bacteria. However, these natural clays are too variable to be used in clinical settings. Our study shows that synthetic antibacterial minerals exhibit potent antibacterial activity against topical MRSA infections and increase the rate of wound closure relative to controls. The antibacterial minerals maintain a redox cycle between Fe/Fe and the surfaces of pyrite minerals, which act as a semiconductor and produce reactive oxygen species (ROS), while smectite minerals act as a cation exchange reservoir. Acidic conditions are maintained throughout the application of the hydrated minerals and can mitigate the alkaline pH conditions observed in chronic non-healing wounds. These results provide evidence for the strategy of 'iron overload' to combat antibiotic resistant infections through the maintained release of Fe and generation of ROS via distinct geochemical reactions that can break the chronic wound damage cycle.
新抗生素的研发已经停滞不前，我们正进入抗生素耐药时代，因此需要新的策略。某些天然存在的粘土已被证明能有效杀死对抗生素有耐药性的细菌。然而，这些天然粘土的变数太大，无法在临床环境中使用。我们的研究表明，合成抗菌矿物对局部耐甲氧西林金黄色葡萄球菌（MRSA）感染具有强大的抗菌活性，与对照组相比，能提高伤口愈合率。抗菌矿物在黄铁矿矿物表面保持铁/铁之间的氧化还原循环，黄铁矿矿物作为半导体并产生活性氧（ROS），而蒙脱石矿物作为阳离子交换库。在应用水合矿物的过程中保持酸性条件，可以减轻慢性非愈合性伤口中观察到的碱性 pH 值条件。这些结果为通过持续释放铁和通过独特的地球化学反应产生 ROS 来对抗抗生素耐药性感染的“铁过载”策略提供了证据，这种策略可以打破慢性伤口损伤循环。
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