Brownie C F, Cullen J
Vet Hum Toxicol. 1987 Feb;29(1):34-8.
An isolate of Fusarium moniliforme (M-1225 Cairo #1) was cultured on autoclaved corn and fed daily to 5 ponies at a rate of 2.5 g corn/kg body wt. One pony developed clinical signs of toxicity after 28 days and was sacrificed. The remaining 4 ponies developed no clinical sign of toxicity even after extended exposure. Hematology, serum chemistry, cerebrospinal fluid (CSF), and liver and brain pathology were evaluated as possible diagnostic and prognostic indicators. Hematology was not informative. Aspartate aminotransferase and gamma-glutamyltranspeptidase activities were elevated only in the clinically positive pony. CSF was most informative. Elevated myelin basic protein levels (greater than 14 ng/ml; normal less than 2.0 ng/ml) and cytologic changes consistent with chronic inflammation were observed in the clinically positive pony. Chronic inflammation was also seen in one clinically normal pony. Cytoplasmic vacuolation and clumping were observed in the hepatocytes of all ponies. Brain pathology was consistent with ELEM in the clinically positive pony.
将串珠镰刀菌的一个分离株（M - 1225开罗#1）接种于经高压灭菌的玉米上，然后以2.5克玉米/千克体重的剂量每天喂给5匹小马。28天后，有一匹小马出现中毒临床症状并被处死。其余4匹小马即使在长期接触后也未出现中毒临床症状。对血液学、血清化学、脑脊液（CSF）以及肝脏和脑部病理学进行了评估，作为可能的诊断和预后指标。血液学检查无诊断价值。仅在出现临床症状的小马中，天冬氨酸转氨酶和γ-谷氨酰转肽酶活性升高。脑脊液检查提供的信息最多。在出现临床症状的小马中，观察到髓鞘碱性蛋白水平升高（大于14纳克/毫升；正常小于2.0纳克/毫升）以及与慢性炎症一致的细胞学变化。在一匹临床正常的小马中也观察到了慢性炎症。在所有小马的肝细胞中均观察到细胞质空泡化和聚集现象。在出现临床症状的小马中，脑部病理学检查结果与脑白质营养不良一致。
