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Direct immunoactivation by chemotherapeutic drugs in cancer treatment.

作者信息

Wang Yurui, Song Yiran, He Yazhi, Wang Yang, Maurer Jochen, Kiessling Fabian, Lammers Twan, Wang Feng, Shi Yang

机构信息

Department of Polymer Therapeutics, Institute for Experimental Molecular Imaging, Uniklinik RWTH Aachen and Helmholtz Institute for Biomedical Engineering, Faculty of Medicine, RWTH Aachen University, Aachen 52074, Germany.

Department of Gastroenterology, Shanghai 10th People's Hospital, School of Medicine, Tongji University, Shanghai 200040, PR China.

出版信息

Adv Ther (Weinh). 2023 Dec;6(12):2300209. doi: 10.1002/adtp.202300209. Epub 2023 Sep 15.

DOI:10.1002/adtp.202300209
PMID:38249990
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7615547/
Abstract

The immune system plays a crucial role in recognizing and eliminating pathogenic substances and malignant cells in the body. For cancer treatment, immunotherapy is becoming the standard treatment for many types of cancer and is often combined with chemotherapy. Although chemotherapeutic agents are often reported to have adverse effects, including immunosuppression, they can also play a positive role in immunotherapy by directly stimulating the immune system. This has been demonstrated in preclinical and clinical studies in the past decades. Chemotherapeutics can activate immune cells through different immune receptors and signaling pathways depending on their chemical structure and formulation. In this review, we summarize and discuss the direct immunoactivation effects of chemotherapeutics and possible mechanisms behind these effects. Finally, we prospect chemo-immunotherapeutic combinations for the more effective and safer treatment of cancer.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a0a/7615547/82d7619b7e6f/EMS193368-f007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a0a/7615547/e65ef0f27590/EMS193368-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a0a/7615547/9a1e26fd39fc/EMS193368-f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a0a/7615547/d22b1dd97c1d/EMS193368-f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a0a/7615547/a74d13f73555/EMS193368-f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a0a/7615547/4adf7a22261f/EMS193368-f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a0a/7615547/6a61186e0138/EMS193368-f006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a0a/7615547/82d7619b7e6f/EMS193368-f007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a0a/7615547/e65ef0f27590/EMS193368-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a0a/7615547/9a1e26fd39fc/EMS193368-f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a0a/7615547/d22b1dd97c1d/EMS193368-f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a0a/7615547/a74d13f73555/EMS193368-f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a0a/7615547/4adf7a22261f/EMS193368-f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a0a/7615547/6a61186e0138/EMS193368-f006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a0a/7615547/82d7619b7e6f/EMS193368-f007.jpg

相似文献

[1]
Direct immunoactivation by chemotherapeutic drugs in cancer treatment.

Adv Ther (Weinh). 2023-12

[2]
The need for improvement of the treatment of advanced and metastatic cervical cancer, the rationale for combined chemo-immunotherapy.

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[3]
Immunotherapeutic properties of chemotherapy.

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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
Chemo-Immunotherapy: A New Trend in Cancer Treatment.

Cancers (Basel). 2023-5-25

[10]
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Transl Lung Cancer Res. 2014-2

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本文引用的文献

[1]
Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics.

Genes Dis. 2022-3-18

[2]
Taxanes trigger cancer cell killing in vivo by inducing non-canonical T cell cytotoxicity.

Cancer Cell. 2023-6-12

[3]
Macrophages in immunoregulation and therapeutics.

Signal Transduct Target Ther. 2023-5-22

[4]
Systematic elucidation and pharmacological targeting of tumor-infiltrating regulatory T cell master regulators.

Cancer Cell. 2023-5-8

[5]
Metal-fluorouracil networks with disruption of mitochondrion enhanced ferroptosis for synergistic immune activation.

Theranostics. 2022

[6]
Cell-autonomous Hedgehog signaling controls Th17 polarization and pathogenicity.

Nat Commun. 2022-7-14

[7]
Detection of temozolomide-induced hypermutation and response to PD-1 checkpoint inhibitor in recurrent glioblastoma.

Neurooncol Adv. 2022-5-23

[8]
A TLR4-independent critical role for CD14 in intracellular LPS sensing.

Cell Rep. 2022-5-3

[9]
Immunomodulatory activity of a water-soluble polysaccharide extracted from mussel on cyclophosphamide-induced immunosuppressive mice models.

NPJ Sci Food. 2022-4-27

[10]
Immunosuppressive Signaling Pathways as Targeted Cancer Therapies.

Biomedicines. 2022-3-16

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