School of Biodiversity, One Health and Veterinary Medicine, Graham Kerr Building University of Glasgow, Glasgow, G12 8QQ, UK.
Biogerontology. 2024 Apr;25(2):301-311. doi: 10.1007/s10522-023-10081-8. Epub 2024 Jan 22.
This perspectives paper considers the value of studying telomere biology outside of a biomedical context. I provide illustrative examples of the kinds of questions that evolutionary ecologists have addressed in studies of telomere dynamics in non-model species, primarily metazoan animals, and what this can contribute to our understanding of their evolution, life histories and health. I also discuss why the predicted relationships between telomere dynamics and life history traits, based on the detailed cellular studies in humans and model organisms, are not always found in studies in other species.
这篇观点论文探讨了在生物医学背景之外研究端粒生物学的价值。我提供了进化生态学家在非模式物种(主要是后生动物)的端粒动态研究中所解决的问题类型的说明性示例,以及这如何有助于我们理解它们的进化、生活史和健康。我还讨论了为什么基于人类和模式生物的详细细胞研究预测的端粒动态与生活史特征之间的关系并不总是在其他物种的研究中发现。