Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Translational Health Sciences, Faculty of Health Sciences, University of Bristol, Bristol, UK.
Stress. 2024 Jan;27(1):2297371. doi: 10.1080/10253890.2023.2297371. Epub 2024 Jan 23.
Rhythmicity is a intrinsic feature of biological systems, including the hypothalamic-pituitary-adrenal axis, a mammalian neurohormonal system crucial both in daily life and as a network that responds to stressful stimuli. Circadian and ultradian rhythmicity underlie HPA activity in rodents and in humans, regulating gene expression, metabolism and behavior, and adverse consequences occur when rhythms are disturbed. In the assessment of human disease, the complexity of HPA rhythmicity is rarely acknowledged or understood, and is currently a limitation to better diagnosis and treatment. However, the recent emergence of ambulatory, high frequency and blood-free hormone sampling techniques has the promise to substantially change our understanding of the function of HPA axis in healthy normal life, and provide new opportunities for the diagnosis and treatment of disease.
节律性是生物系统的固有特征，包括下丘脑-垂体-肾上腺轴，这是一种在日常生活中至关重要的哺乳动物神经激素系统，也是对应激刺激做出反应的网络。昼夜节律和超昼夜节律是啮齿动物和人类 HPA 活动的基础，调节基因表达、代谢和行为，当节律紊乱时会产生不良后果。在人类疾病的评估中，HPA 节律性的复杂性很少得到承认或理解，目前这是更好地诊断和治疗的一个限制。然而，最近出现的可移动、高频和无血激素采样技术有望极大地改变我们对 HPA 轴在健康正常生活中的功能的理解，并为疾病的诊断和治疗提供新的机会。
