State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China.
College of Medical Informatics, Chongqing Medical University, Chongqing, China.
Int J Hyperthermia. 2024;41(1):2304264. doi: 10.1080/02656736.2024.2304264. Epub 2024 Jan 23.
Long-term re-intervention after ultrasound-guided high intensity focused ultrasound (USgHIFU) ablation was reported, and the prediction of non-perfusion volume ratio (NPVR) in differently aged patients with uterine fibroids (UFs) was explored.
Patients with UFs who underwent USgHIFU ablation from January 2012 to December 2019 were enrolled and divided into < 40-year-old and ≥ 40-year-old groups. Cox regression was used to analyze the influencing factors of re-intervention rate, and receiver operating characteristic (ROC) curve was used to analyze the correlation between NPVR and re-intervention rate.
A total of 2141 patients were enrolled, and 1558 patients were successfully followed up. The 10-year cumulative re-intervention rate was 21.9%, and the < 40-year-old group had a significantly higher rate than the ≥ 40-year-old group (30.8% vs. 19.1%, < 0.001). NPVR was an independent risk factor in both two groups. When the NPVR reached 80.5% in the < 40-year-old group and 75.5% in the ≥ 40-year-old group, the risk of long-term re-intervention was satisfactory.
The long-term outcome of USgHIFU is promising. The re-intervention rate is related to NPVR in differently aged patients. Young patients need a high NPVR to reduce re-intervention risk.
有报道称，在超声引导高强度聚焦超声（USgHIFU）消融后需要进行长期的再次干预，本研究旨在探讨不同年龄段子宫肌瘤（UFs）患者非灌注体积比（NPVR）对再次干预的预测价值。
本研究回顾性分析了 2012 年 1 月至 2019 年 12 月期间因 UFs 接受 USgHIFU 消融治疗的患者，根据年龄将患者分为<40 岁和≥40 岁两组。采用 Cox 回归分析影响再次干预率的因素，采用受试者工作特征（ROC）曲线分析 NPVR 与再次干预率的相关性。
共纳入 2141 例患者，其中 1558 例患者成功完成随访。10 年累积再次干预率为 21.9%，<40 岁组明显高于≥40 岁组（30.8% vs. 19.1%，<0.001）。NPVR 是两组患者的独立危险因素。当<40 岁组 NPVR 达到 80.5%，≥40 岁组 NPVR 达到 75.5%时，长期再次干预的风险较低。
USgHIFU 的长期疗效令人满意。再次干预率与不同年龄段患者的 NPVR 有关。年轻患者需要较高的 NPVR 才能降低再次干预的风险。
