Department of Neurosurgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany.
Department of Anesthesiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany.
Acta Neurochir (Wien). 2024 Jan 23;166(1):29. doi: 10.1007/s00701-024-05909-2.
Despite aneurysmal subarachnoid haemorrhage (aSAH) patients often experiencing physical and mental disabilities impacting their quality of life (QoL), routine assessment of long-term QoL data and predictive tools are limited. This study evaluates the newly developed "functional recovery expected after subarachnoid haemorrhage" (FRESH) scores with long-term outcomes and QoL in European aSAH patients.
FRESH, FRESH-cog, and FRESH-quol scores were retrospectively obtained from aSAH patients. Patients were contacted, and the modified Rankin Scale (mRS), extended short form-36 (SF-36), and telephone interview for cognitive status (TICS) were collected and performed. The prognostic and empirical outcomes were compared.
Out of 374 patients, 171 patients (54.1%) completed the SF-36, and 154 patients completed the TICS. The SF-36 analysis showed that 32.7% had below-average physical component summary (PCS) scores, and 39.8% had below-average mental component summary (MCS) scores. There was no significant correlation between the FRESH score and PCS (p = 0.09736), MCS (p = 0.1796), TICS (p = 0.7484), or mRS 10-82 months (average 46 months) post bleeding (p = 0.024), respectively. There was also no significant correlation found for "FRESH-cog vs. TICS" (p = 0.0311), "FRESH-quol vs. PCS" (p = 0.0204), "FRESH-quol vs. MCS" (p = 0.1361) and "FRESH-quol vs. TICS" (p = 0.1608).
This study found no correlation between FRESH scores and validated QoL tools in a European population of aSAH patients. The study highlights the complexity of reliable long-term QoL prognostication in aSAH patients and emphasises the need for further prospective research to also focus on QoL as an important outcome parameter.
尽管动脉瘤性蛛网膜下腔出血（aSAH）患者常经历影响其生活质量（QoL）的身体和精神残疾，但长期 QoL 数据和预测工具的常规评估仍有限。本研究评估了新开发的“蛛网膜下腔出血后预期功能恢复”（FRESH）评分与欧洲 aSAH 患者的长期结局和 QoL 的相关性。
回顾性获取 aSAH 患者的 FRESH、FRESH-cog 和 FRESH-quol 评分。联系患者并收集和执行改良 Rankin 量表（mRS）、扩展短表单-36（SF-36）和电话认知状态访谈（TICS）。比较了预测和经验性结果。
在 374 名患者中，171 名患者（54.1%）完成了 SF-36，154 名患者完成了 TICS。SF-36 分析显示，32.7%的患者生理成分综合评分（PCS）较低，39.8%的患者心理成分综合评分（MCS）较低。FRESH 评分与 PCS（p=0.09736）、MCS（p=0.1796）、TICS（p=0.7484）或出血后 10-82 个月（平均 46 个月）的 mRS 之间均无显著相关性（p=0.024）。“FRESH-cog 与 TICS”（p=0.0311）、“FRESH-quol 与 PCS”（p=0.0204）、“FRESH-quol 与 MCS”（p=0.1361）和“FRESH-quol 与 TICS”（p=0.1608）之间也未发现显著相关性。
本研究在欧洲 aSAH 患者人群中未发现 FRESH 评分与经验证的 QoL 工具之间存在相关性。该研究强调了可靠的长期 QoL 预测在 aSAH 患者中的复杂性，并强调需要进一步进行前瞻性研究，也将 QoL 作为一个重要的结局参数进行关注。
