Roux Christian, Briot Karine
Université de Paris, Centre de Recherche Epidémiologie et Statistiques, Unité Mixte de Recherche 1153, Institut National de la Santé et de la Recherche Médicale, Paris, France; Service de Rhumatologie, Assistance Publique-Hopitaux de Paris, Hospital Cochin, Paris, France.
Université de Paris, Centre de Recherche Epidémiologie et Statistiques, Unité Mixte de Recherche 1153, Institut National de la Santé et de la Recherche Médicale, Paris, France; Service de Rhumatologie, Assistance Publique-Hopitaux de Paris, Hospital Cochin, Paris, France.
Lancet Rheumatol. 2020 Feb;2(2):e110-e119. doi: 10.1016/S2665-9913(19)30136-5. Epub 2020 Jan 29.
The number of fractures related to osteoporosis is expected to increase dramatically in the next few decades because of an increase in the number of elderly patients at high risk of falls and fractures. Developments in the diagnosis and treatment of osteoporosis might change our strategies for management of patients with osteoporosis: the imminent risk of fracture concept, the issue of how to correctly sequence treatment, the potential effectiveness of screening, and goal-directed treatment strategies. Despite advances, few patients receive appropriate treatment for osteoporosis, even after a fracture. The crisis in the treatment of osteoporosis is related to several factors, including the fears and beliefs that patients and physicians have about the adverse effects of treatments. Strategies to address this crisis pose a considerable challenge; nonetheless, prevention of fragility fractures is within our reach. To that end, careful selection of patients at high risk of fracture, selection of the best therapeutic strategy, and accurate communication about fracture risk and bone fragility must be improved.
由于高危跌倒和骨折的老年患者数量增加,预计在未来几十年中与骨质疏松症相关的骨折数量将急剧上升。骨质疏松症诊断和治疗方面的进展可能会改变我们对骨质疏松症患者的管理策略:即将发生骨折的风险概念、如何正确安排治疗顺序的问题、筛查的潜在有效性以及目标导向的治疗策略。尽管取得了进展,但即使在发生骨折后,仍有少数患者接受了适当的骨质疏松症治疗。骨质疏松症治疗方面的危机与几个因素有关,包括患者和医生对治疗不良反应的恐惧和看法。应对这一危机的策略构成了相当大的挑战;尽管如此,预防脆性骨折是我们力所能及的。为此,必须改进对高骨折风险患者的仔细筛选、最佳治疗策略的选择以及关于骨折风险和骨脆性的准确沟通。