Shin Yeo Jin, Kwon Ki-Sun, Suh Yousin, Lee Kwang-Pyo
Aging Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea.
Department of Bioscience, KRIBB School, Korea University of Science and Technology (UST), Daejeon, Republic of Korea.
Front Mol Biosci. 2024 Jan 9;10:1308274. doi: 10.3389/fmolb.2023.1308274. eCollection 2023.
Muscle aging is a complex physiological process that leads to the progressive decline in muscle mass and function, contributing to debilitating conditions in the elderly such as sarcopenia. In recent years, non-coding RNAs (ncRNAs) have been increasingly recognized as major regulators of muscle aging and related cellular processes. Here, we comprehensively review the emerging role of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), in the regulation of muscle aging. We also discuss how targeting these ncRNAs can be explored for the development of novel interventions to combat age-related muscle decline. The insights provided in this review offer a promising avenue for future research and therapeutic strategies aimed at improving muscle health during aging.
肌肉衰老 是一个复杂的生理过程，会导致肌肉质量和功能逐渐下降，从而引发老年人的衰弱状况，如肌肉减少症。近年来，非编码RNA（ncRNAs）越来越被认为是肌肉衰老和相关细胞过程的主要调节因子。在此，我们全面综述了ncRNAs，包括微小RNA（miRNAs）、长链非编码RNA（lncRNAs）和环状RNA（circRNAs）在肌肉衰老调节中的新兴作用。我们还讨论了如何探索靶向这些ncRNAs来开发新的干预措施，以对抗与年龄相关的肌肉衰退。本综述提供的见解为未来旨在改善衰老过程中肌肉健康的研究和治疗策略提供了一条有前景的途径。
