在一个基于大规模普通人群的样本中，应激负荷与社会人口学因素、抑郁症状、生活方式及健康特征之间的关联。
Associations of allostatic load with sociodemographic factors, depressive symptoms, lifestyle, and health characteristics in a large general population-based sample.
作者信息
Honkalampi Kirsi, Kraav Siiri-Liisi, Kerr Philippe, Juster Robert-Paul, Virtanen Marianna, Hintsa Taina, Partonen Timo, Lehto Soili M
机构信息
School of Educational Sciences and Psychology, University of Eastern Finland, Joensuu, Finland.
Department of Social Sciences, University of Eastern Finland, Kuopio, Finland.
出版信息
J Affect Disord. 2024 Apr 1;350:784-791. doi: 10.1016/j.jad.2024.01.189. Epub 2024 Jan 23.
OBJECTIVE
We examined the associations between allostatic load (AL) and sociodemographic factors, depressive symptoms, lifestyle and health characteristics in a population-based sample of 4993 adults in Finland.
METHODS
Thirteen biomarkers were used to construct AL. High AL was defined as scoring highly in ≥4 items.
RESULTS
AL scores of 4 and above were exceeded in the age group of 45-54 years in men and 65-74 years in women. Age was the strongest predictor for belonging to the high AL score group. In addition, elevated depressive symptoms (BDI-6 ≥ 4), male sex, not engaging in physical exercise, high alcohol use and a low level of education were associated with an increased likelihood of belonging to the high AL group.
CONCLUSION
The older the participants were, the greater their AL burden was. However, AL burden increased more steeply as a function of age in men. In addition to lifestyle interventions, effective prevention strategies for depression at the population level could have a major public health impact in reducing the accumulation of AL burden.
目的
我们在芬兰4993名成年人的基于人群的样本中，研究了累积生理失调负荷（AL）与社会人口学因素、抑郁症状、生活方式和健康特征之间的关联。
方法
使用13种生物标志物构建AL。高AL被定义为在≥4项指标中得分较高。
结果
男性45 - 54岁年龄组以及女性65 - 74岁年龄组的AL得分超过了4分及以上。年龄是属于高AL得分组的最强预测因素。此外，抑郁症状加重（贝克抑郁量表-6≥4）、男性、不进行体育锻炼、大量饮酒和低教育水平与属于高AL组的可能性增加有关。
结论
参与者年龄越大，其AL负担越重。然而，男性的AL负担随年龄增长上升得更为陡峭。除生活方式干预外，针对人群层面抑郁症的有效预防策略可能对减轻AL负担的累积产生重大公共卫生影响。
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