To synthesize novel more potent trypanocidal and leishmanicidal agents. Hantzsch's synthetic strategy was used to synthesize 1,3-thiazole-4-carboxylates and their -benzylated derivatives. 28 new thiazole-carboxylates and their -benzylated derivatives were established to test their trypanocidal and leishmanicidal activities. From both series, compounds , , , and exhibited a better or comparable trypanocidal profile to benznidazole. Among all tested compounds, was found to be the most potent and was better than benznidazole. Further variation of substituents around 1,3-thiazole-4-carboxylates and or hydrazinyl moiety may assist in establishing better and more potent trypanocidal and leishmanicidal agents.