Zhou Xuan, Su Manman, Lu Jungu, Li Deming, Niu Xinhui, Wang Yi
Department of Regenerative Medicine, School of Pharmaceutical Sciences, Jilin University, Changchun 130012, China.
Molecules. 2024 Jan 21;29(2):531. doi: 10.3390/molecules29020531.
It has been found that the development of some cancers can be attributed to obesity, which is associated with the excessive intake of lipids. Cancer cells undergo metabolic reprogramming, shifting from utilizing glucose to fatty acids (FAs) for energy. CD36, a lipid transporter, is highly expressed in certain kinds of cancer cells. High expressions of CD36 in tumor cells triggers FA uptake and lipid accumulation, promoting rapid tumor growth and initiating metastasis. Meanwhile, immune cells in the tumor microenvironment overexpress CD36 and undergo metabolic reprogramming. CD36-mediated FA uptake leads to lipid accumulation and has immunosuppressive effects. This paper reviews the types of FAs associated with cancer, high expressions of CD36 that promote cancer development and progression, effects of CD36 on different immune cells in the tumor microenvironment, and the current status of CD36 as a therapeutic target for the treatment of tumors with high CD36 expression.
研究发现，某些癌症的发生发展可归因于肥胖，而肥胖与脂质摄入过多有关。癌细胞会经历代谢重编程，从利用葡萄糖转变为利用脂肪酸（FAs）获取能量。脂质转运蛋白CD36在某些类型的癌细胞中高表达。肿瘤细胞中CD36的高表达会触发脂肪酸摄取和脂质积累，促进肿瘤快速生长并引发转移。同时，肿瘤微环境中的免疫细胞也会过度表达CD36并经历代谢重编程。CD36介导的脂肪酸摄取会导致脂质积累并具有免疫抑制作用。本文综述了与癌症相关的脂肪酸类型、促进癌症发生发展的CD36高表达、CD36对肿瘤微环境中不同免疫细胞的影响，以及CD36作为高表达CD36肿瘤治疗靶点的研究现状。
