循环代谢物与前列腺增生的关系：一项孟德尔随机化研究。
The relationship between circulating metabolites and prostate hyperplasia: a Mendelian randomization study.
机构信息
Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, No. 10 Huadong Road, Xingning District, Nanning, 530000, People's Republic of China.
The Second People's Hospital of Zhaoqing, Zhaoqing, 526000, China.
出版信息
Aging Clin Exp Res. 2024 Jan 28;36(1):10. doi: 10.1007/s40520-023-02669-4.
BACKGROUND
Circulating metabolites (CM) play a pivotal role in our overall health, yet the current evidence concerning the involvement of diverse CM in benign prostatic hyperplasia (BPH) remains limited. Mendelian randomization (MR) offers a promising avenue to explore the potential impact of CM on BPH.
METHODS
In a forward MR analysis, a cohort of 249 circulating metabolites was employed as exposures to investigate their potential associations with BPH risk. Conversely, in a reverse MR analysis, BPH was employed as an exposure to assess its effects on CM.
RESULTS
The forward MR analysis discerned a linkage between six metabolites and BPH, with careful consideration to excluding heterogeneity and pleiotropy. Subsequently, the reverse MR analysis unveiled that nine metabolic compounds, mainly comprising phospholipids and triglycerides, potentially exhibit elevated levels in BPH patients.
CONCLUSION
Bidirectional MR analysis furnishes genetic insight into the interplay between CM and BPH. The prominence of lipids and triglycerides emerges as significant factors intricately linked to BPH risk.
背景
循环代谢物在整体健康中起着关键作用，但目前关于不同循环代谢物在良性前列腺增生（BPH）中的作用的证据仍然有限。孟德尔随机化（MR）为探索循环代谢物对 BPH 的潜在影响提供了一个有前途的途径。
方法
在正向 MR 分析中，使用了 249 种循环代谢物作为暴露因素，以研究它们与 BPH 风险的潜在关联。相反，在反向 MR 分析中，BPH 被用作暴露因素，以评估其对 CM 的影响。
结果
正向 MR 分析发现了六种代谢物与 BPH 之间的联系，同时仔细考虑了排除异质性和多效性。随后，反向 MR 分析揭示了 9 种代谢物，主要包括磷脂和甘油三酯，在 BPH 患者中可能表现出升高的水平。
结论
双向 MR 分析提供了关于循环代谢物和 BPH 之间相互作用的遗传见解。脂质和甘油三酯的重要性突显出来，它们是与 BPH 风险密切相关的重要因素。
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