美国恶性脑肿瘤死亡率的性别、种族和地域差异。

Gender, Racial, and Geographical Disparities in Malignant Brain Tumor Mortality in the USA.

机构信息

Department of Internal Medicine, New York Medical College at Saint Michael's Medical Center, Newark, New Jersey, USA.

Shanghai Medical College, Fudan University, Shanghai, China.

出版信息

Oncology. 2024;102(8):703-709. doi: 10.1159/000536486. Epub 2024 Jan 27.

DOI:10.1159/000536486

PMID:38281482

Abstract

INTRODUCTION

Malignant brain tumors are malignancies which are known for their low survival rates. Despite advancements in treatments in the last decade, the disparities in malignant brain cancer mortality among the US population remain unclear.

METHODS

We analyzed death certificate data from the US CDC WONDER from 1999 to 2020 to determine the longitudinal trends of malignant brain tumor mortality. Malignant brain tumor (ICD-10 C71.0-71.9) was listed as the underlying cause of death. Age-adjusted mortality rates (AAMRs) per 100,000 individuals were calculated by standardizing the AAMR to the year 2000 US population.

RESULTS

From 1999 to 2020, there were 306,375 deaths due to malignant brain tumors. The AAMR decreased from 5.57 (95% CI, 5.47-5.67) per 100,000 individuals in 1999 to 5.40 (95% CI, 5.31-5.48) per 100,000 individuals in 2020, with an annual percent decrease of -0.05 (95% CI, -0.22, 0.12). Whites had the highest AAMR (6.05 [95% CI, 6.02-6.07] per 100,000 individuals), followed by Hispanics (3.70 [95% CI, 3.64-3.76]) per 100,000 individuals, blacks (3.09 [95% CI, 3.04-3.14] per 100,000 individuals), American Indians (2.82 [95% CI, 2.64-3.00] per 100,000 individuals), and Asians (2.44 [95% CI, 2.38-2.50] per 100,000 individuals). The highest AAMRs were reported in the Midwest region (5.58 [95% CI, 5.54-5.62] per 100,000 individuals) and the rural regions (5.66 [95% CI, 5.61-5.71] per 100,000 individuals).

CONCLUSIONS

Our study highlights the mortality disparity among different races, geographic regions, and urbanization levels. The findings underscore the importance of addressing the disparities in malignant brain tumors that existed among males, white individuals, and rural populations.

摘要

简介

恶性脑肿瘤是一种存活率较低的恶性肿瘤。尽管在过去十年中治疗取得了进展，但美国人群中恶性脑癌死亡率的差异仍不清楚。

方法

我们分析了美国疾病控制与预防中心（CDC） Wonder 从 1999 年到 2020 年的死亡证明数据，以确定恶性脑肿瘤死亡率的纵向趋势。恶性脑肿瘤（ICD-10 C71.0-71.9）被列为死亡的根本原因。按每 10 万人标准化的年龄调整死亡率（AAMR）计算为每 10 万人 5.57（95%置信区间，5.47-5.67）。

结果

1999 年至 2020 年期间，有 306375 人死于恶性脑肿瘤。AAMR 从 1999 年的每 10 万人 5.57（95%置信区间，5.47-5.67）降至 2020 年的每 10 万人 5.40（95%置信区间，5.31-5.48），每年下降 0.05（95%置信区间，-0.22，0.12）。白人的 AAMR 最高（每 10 万人 6.05 [95%置信区间，6.02-6.07]），其次是西班牙裔（每 10 万人 3.70 [95%置信区间，3.64-3.76]），黑人（每 10 万人 3.09 [95%置信区间，3.04-3.14]），美洲印第安人（每 10 万人 2.82 [95%置信区间，2.64-3.00]）和亚洲人（每 10 万人 2.44 [95%置信区间，2.38-2.50]）。中西部地区（每 10 万人 5.58 [95%置信区间，5.54-5.62]）和农村地区（每 10 万人 5.66 [95%置信区间，5.61-5.71]）报告的 AAMR 最高。