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新生儿腹部横纹肌肉瘤伴症状性脊髓硬膜外压迫:一例报告

Abdominal rhabdoid tumor presenting with symptomatic spinal epidural compression in a newborn. A case report.

作者信息

Montalto Shana, Di Filippo Michela, Capra Valeria, Manzitti Carla, Sementa Angela Rita, De Marco Patrizia, Ognibene Marzia, Sertorio Fiammetta, Sorrentino Stefania

机构信息

Pediatric Infectious Diseases Unit, IRCCS IstitutoGianninaGaslini, Genoa, Italy.

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.

出版信息

Front Pediatr. 2024 Jan 12;11:1337760. doi: 10.3389/fped.2023.1337760. eCollection 2023.

Abstract

The occurrence of an abdominal tumor invading the spinal canal and causing symptoms of epidural compression is rare in an infant, and exceptional at birth. Peripheral neuroblastic tumors are by far the most common cause. Emergency chemotherapy is commonly curative, though permanent sequelae are possible. Although other malignancies may be involved, no case of rhabdoid tumors at birth has been reported. We describe the case of a neonate who presented symptoms of spinal epidural compression at birth secondary to a rhabdoid tumor. As expected with this highly malignant tumor, the patient experienced a rapidly progressive clinical course and died within three months of diagnosis.

摘要

腹部肿瘤侵犯椎管并导致硬膜外压迫症状在婴儿中很少见,在出生时更是罕见。外周神经母细胞瘤是迄今为止最常见的病因。紧急化疗通常可治愈,不过可能会留下永久性后遗症。虽然可能涉及其他恶性肿瘤,但尚未有出生时患横纹肌肉瘤的病例报道。我们描述了一名新生儿的病例,该新生儿出生时因横纹肌肉瘤出现脊髓硬膜外压迫症状。正如这种高度恶性肿瘤所预期的那样,患者经历了快速进展的临床病程,并在诊断后三个月内死亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e823/10811000/fb495c7672d1/fped-11-1337760-g001.jpg

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