Matsuura Yuma, Fuse Shinichiro
Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya 464-8601, Japan.
Chem Commun (Camb). 2024 Feb 27;60(18):2497-2500. doi: 10.1039/d3cc06308a.
A rapid nucleophilic substitution reaction was developed using carbocations generated from diarylmethanol and trifluoromethanesulfonic acid. Undesired reactions caused by the carbocations were suppressed, presumably due to the rapid and uniform generation of carbocations and the subsequent rapid and uniform distribution of nucleophiles by the micro-flow technology.
利用二芳基甲醇和三氟甲磺酸生成的碳正离子开发了一种快速亲核取代反应。由碳正离子引起的不期望的反应得到了抑制,推测这是由于通过微流技术快速且均匀地生成碳正离子以及随后亲核试剂的快速且均匀分布。