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微流杂原子烷基化:三氟甲磺酸介导的碳正离子快速生成及随后的亲核试剂加成。

Micro-flow heteroatom alkylation TfOH-mediated rapid generation of carbocations and subsequent nucleophile addition.

作者信息

Matsuura Yuma, Fuse Shinichiro

机构信息

Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya 464-8601, Japan.

出版信息

Chem Commun (Camb). 2024 Feb 27;60(18):2497-2500. doi: 10.1039/d3cc06308a.

Abstract

A rapid nucleophilic substitution reaction was developed using carbocations generated from diarylmethanol and trifluoromethanesulfonic acid. Undesired reactions caused by the carbocations were suppressed, presumably due to the rapid and uniform generation of carbocations and the subsequent rapid and uniform distribution of nucleophiles by the micro-flow technology.

摘要

利用二芳基甲醇和三氟甲磺酸生成的碳正离子开发了一种快速亲核取代反应。由碳正离子引起的不期望的反应得到了抑制,推测这是由于通过微流技术快速且均匀地生成碳正离子以及随后亲核试剂的快速且均匀分布。

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