Ruffin Ayana T, Wittling Megen C, Cole Anna C, Paulos Chrystal M
Department of Surgery, Emory University, Atlanta, Georgia.
Department of Microbiology and Immunology, Emory University, Atlanta, Georgia.
Clin Cancer Res. 2024 Apr 15;30(8):1431-1433. doi: 10.1158/1078-0432.CCR-23-3466.
Systemic administration of homeostatic γ-chain cytokines mediates antitumor responses in some patients treated with adoptive immunotherapy. Yet many patients experience toxic side effects. New work presented herein suggests these limitations can be overcome by membrane-tethering IL15 and IL21 to T-cell products. This finding has major implications in advancing medicine. See related article by Nguyen et al., p. 1555.
稳态γ链细胞因子的全身给药在一些接受过过继性免疫疗法治疗的患者中可介导抗肿瘤反应。然而,许多患者会出现毒副作用。本文所展示的新研究表明,将白细胞介素15(IL15)和白细胞介素21(IL21)与T细胞产物进行膜系留可以克服这些局限性。这一发现对医学发展具有重大意义。见阮等人的相关文章,第1555页。