Hassan M N, Reches A, Kuhn C, Higgins D, Fahn S
Clin Neuropharmacol. 1986;9(1):71-8. doi: 10.1097/00002826-198602000-00008.
The occurrence of adverse extrapyramidal effects following metoclopramide (MCP) therapy has been well documented in humans. In rats, MCP produced catalepsy and inhibited apomorphine-induced stereotypy, locomotor activity, and rotational behavior. MCP also accelerated dopamine turnover, potently stimulated prolactin release, and, at high concentrations, inhibited [3H]spiperone binding to striatal membranes. These behavioral and biochemical effects induced by MCP were similar to those observed with haloperidol. We conclude that MCP possesses most of the pharmacological properties of neuroleptic agents.
甲氧氯普胺（MCP）治疗后发生锥体外系不良反应在人类中已有充分记录。在大鼠中，MCP会产生僵住症，并抑制阿扑吗啡诱导的刻板行为、运动活动和旋转行为。MCP还加速多巴胺周转，有力地刺激催乳素释放，且在高浓度时抑制[3H]螺哌隆与纹状体膜的结合。MCP诱导的这些行为和生化效应与氟哌啶醇观察到的效应相似。我们得出结论，MCP具有抗精神病药物的大多数药理特性。
