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纳米乳剂:十年研究总结及最新进展。

Nanoemulsions: Summary of a Decade of Research and Recent Advances.

机构信息

Department of Pharmaceutics & Pharmaceutical Technology, L.M. College of Pharmacy, Ahmedabad, India, 380009.

Pharmacy Section, L.M. College of Pharmacy, Ahmedabad, India, 380009.

出版信息

Nanomedicine (Lond). 2024 Mar;19(6):519-536. doi: 10.2217/nnm-2023-0199. Epub 2024 Jan 31.


DOI:10.2217/nnm-2023-0199
PMID:38293801
Abstract

Nanoemulsions consist of a combination of several components such as oil, water, emulsifiers, surfactants and cosurfactants. Various techniques for producing nanoemulsions include high-energy and low-energy approaches such as high-pressure homogenization, microfluidization, jet disperser and phase inversion methods. The properties of a formulation can be influenced by elements such as the composition, concentration, size and charge of droplets, which in turn can affect the technique of manufacture. Characterization is conducted by the assessment of several factors such as physical properties, pH analysis, viscosity measurement and refractive index determination. This article offers a thorough examination of the latest developments in nanoemulsion technology, with a focus on their wide-ranging applications and promising future possibilities. It also discusses the administration of nanoemulsions through several methods.

摘要

纳米乳由多种成分组成,如油、水、乳化剂、表面活性剂和助表面活性剂。制备纳米乳的各种技术包括高能和低能方法,如高压均质、微流化、射流分散器和相转变方法。制剂的性质可以受到各种因素的影响,如液滴的组成、浓度、大小和电荷,这反过来又会影响制造技术。通过评估物理性质、pH 值分析、粘度测量和折射率测定等几个因素来进行表征。本文全面介绍了纳米乳技术的最新发展,重点介绍了其广泛的应用和有前途的未来可能性。还讨论了通过几种方法给予纳米乳。

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