Department of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Pharmacol Res. 2024 Mar;201:107089. doi: 10.1016/j.phrs.2024.107089. Epub 2024 Jan 29.
Chronic pain has been proven to be an independent disease, other than an accompanying symptom of certain diseases. Interleukin-18 (IL-18), a pro-inflammatory cytokine with pleiotropic biological effects, participates in immune modulation, inflammatory response, tumor growth, as well as the process of chronic pain. Compelling evidence suggests that IL-18 is upregulated in the occurrence of chronic pain. Antagonism or inhibition of IL-18 expression can alleviate the occurrence and development of chronic pain. And IL-18 is located in microglia, while IL-18R is mostly located in astrocytes in the spinal cord. This indicates that the interaction between microglia and astrocytes mediated by the IL-18/IL-18R axis is involved in the occurrence of chronic pain. In this review, we described the role and mechanism of IL-18 in different types of chronic pain. This review provides strong evidence that IL-18 is a potential therapeutic target in pain management.
慢性疼痛已被证明是一种独立的疾病，而不是某些疾病的伴随症状。白细胞介素-18（IL-18）是一种具有多种生物学效应的促炎细胞因子，参与免疫调节、炎症反应、肿瘤生长以及慢性疼痛的过程。大量证据表明，IL-18 在慢性疼痛的发生中上调。拮抗或抑制 IL-18 的表达可以减轻慢性疼痛的发生和发展。而且，IL-18 位于小胶质细胞中，而 IL-18R 主要位于脊髓中的星形胶质细胞中。这表明 IL-18/IL-18R 轴介导的小胶质细胞和星形胶质细胞之间的相互作用参与了慢性疼痛的发生。在这篇综述中，我们描述了 IL-18 在不同类型慢性疼痛中的作用和机制。这篇综述提供了强有力的证据表明，IL-18 是疼痛管理中一个有潜力的治疗靶点。
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