Takahashi Hidenori, Hamasaki Shunsuke, Tanaka Hideyuki, Sakamoto Yasuo, Kawasaki Reina, Mitsui Norikazu, Morikita Tatsuma, Oda Hisanobu
Dept. of Comprehensive Oncology, Saiseikai Kumamoto Hospital.
Gan To Kagaku Ryoho. 2023 Dec;50(13):1647-1649.
A 74-year-old male presenting with bloody stools was diagnosed with advanced rectal cancer. He underwent robot- assisted low anterior resection and temporary ileostomy. Cefmetazole(CMZ)was administered during surgery and on postoperative day(POD)1. His postoperative course was generally good. On POD8, he developed abdominal fullness, vomiting, renal dysfunction, and hyperkalemia. Plain CT revealed small bowel ileus and outlet obstruction with ileostomy was suspected. A nasogastric tube was placed in the stomach, and a balloon catheter was inserted from the ileostomy to the oral side of the ileum. The patient went into shock on the same day and was transferred to a high-care unit. Contrast-enhanced CT indicated pneumatosis intestinalis of the small bowel and portal venous gas. However, the wall of the small bowel was enhanced, so the patient was observed carefully without attempting an operation. The patient's condition improved with systemic management. On POD10, a stool culture from the ileostomy tested positive for CD toxin. Clostridium difficile enteritis(CDE)was diagnosed. The condition improved with systemic control. On POD52, paralytic ileus recurred, and his stool tested positive for the CD toxin again. The ileus improved with conservative treatment. On POD70, the patient was transferred to the hospital for rehabilitation. We report a case of CDE with ileostomy for rectal cancer surgery.
一名74岁男性因便血就诊,被诊断为晚期直肠癌。他接受了机器人辅助低位前切除术和临时回肠造口术。手术期间及术后第1天给予头孢美唑(CMZ)。他的术后恢复过程总体良好。术后第8天,他出现腹胀、呕吐、肾功能不全和高钾血症。平扫CT显示小肠肠梗阻,怀疑回肠造口处有出口梗阻。在胃内放置了鼻胃管,并从回肠造口插入气囊导管至回肠口腔侧。患者于同一天休克,被转至重症监护病房。增强CT显示小肠肠壁积气和门静脉积气。然而,小肠壁有强化,因此对患者进行了密切观察,未尝试手术。通过全身治疗,患者病情好转。术后第10天,回肠造口处的粪便培养检测出艰难梭菌毒素呈阳性。诊断为艰难梭菌肠炎(CDE)。通过全身控制,病情好转。术后第52天,麻痹性肠梗阻复发,他的粪便艰难梭菌毒素检测再次呈阳性。通过保守治疗,肠梗阻有所改善。术后第70天,患者转至医院进行康复治疗。我们报告一例直肠癌手术行回肠造口术后发生CDE的病例。