伴有纤维肌瘤样间质的肾细胞癌中的复发性突变：2例肿瘤报告
Recurrent Mutations in Renal Cell Carcinoma With Fibromyomatous Stroma: A Report of 2 Tumors.
作者信息
Palathingal Bava Ejas, Gupta Nilesh, Alruwaii Fatimah I, Nelson Ryan, Al-Obaidy Khaleel I
机构信息
Department of Pathology and Laboratory Medicine, Henry Ford Health, Detroit, MI, USA.
Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, MI, USA.
出版信息
Int J Surg Pathol. 2024 Oct;32(7):1409-1414. doi: 10.1177/10668969241228295. Epub 2024 Feb 4.
Renal cell carcinoma with fibromyomatous stroma, recognized as a provisional entity in the current 2022 World Health Organization classification of renal neoplasms, is rare. Recent evidence suggests recurrent alterations in the mTOR pathway, supporting its recognition as a distinct entity. Herein, we report 2 renal cell carcinomas with fibromyomatous stroma with mutations occurring in 62- and 72-year-old women and review the literature to support its recognition as a distinct entity, focusing on the characteristic morphology, immunohistochemical staining patterns as well as genetic alterations.
肾细胞癌伴纤维肌瘤样间质在2022年世界卫生组织当前的肾肿瘤分类中被视为一个暂定实体，较为罕见。最近的证据表明mTOR通路存在反复改变，支持将其认定为一个独特的实体。在此，我们报告2例肾细胞癌伴纤维肌瘤样间质，分别发生在62岁和72岁女性中，并复习文献以支持将其认定为一个独特的实体，重点关注其特征性形态、免疫组化染色模式以及基因改变。
Zotero 插件