Dr. Phillip Frost Department of Dermatology and Miami Itch Center, Miller School of Medicine, University of Miami, Miami.
NEJM Evid. 2023 Nov;2(11):EVIDe2300227. doi: 10.1056/EVIDe2300227. Epub 2023 Oct 24.
Chronic kidney disease-associated pruritus (CKD-aP), formerly termed uremic pruritus, is a severely distressing condition that is common (60% of patients on dialysis) and frequently underdiagnosed and untreated. The pruritus can be severe enough to diminish sleep and is associated with worse mortality rates, as demonstrated in several large studies. It can also occur in nondialysis patients with stage 3 to 5 CKD, with an increasing prevalence in patients with worsening kidney function, age, and medical comorbidities. The pathophysiology likely involves many factors and molecules..
慢性肾脏病相关性瘙痒症（CKD-aP），以前称为尿毒症瘙痒症，是一种严重的困扰性疾病，较为常见（透析患者中 60%），且常被漏诊和未予治疗。瘙痒症可能非常严重，导致睡眠减少，并与更高的死亡率相关，这在几项大型研究中得到了证实。它也可能发生在非透析的 3 至 5 期 CKD 患者中，随着肾功能恶化、年龄增长和合并症增多，其患病率逐渐增加。其发病机制可能涉及多种因素和分子。
