恶性高钙血症：一例淋巴瘤相关维生素 D 介导的高钙血症。
Hypercalcaemia of malignancy: a case of vitamin-D-mediated hypercalcaemia in lymphoma.
机构信息
Medicine, UC San Diego, La Jolla, California, USA.
Medicine, UC San Francisco, San Francisco, California, USA.
出版信息
BMJ Case Rep. 2024 Feb 6;17(2):e256126. doi: 10.1136/bcr-2023-256126.
Hypercalcaemia of malignancy (HCM) is a paraneoplastic syndrome that often portends a poor prognosis. We present an extremely rare (<1%) case of HCM due to extrarenal calcitriol (1,25-(OH)D) production in a patient with splenic marginal zone lymphoma. A man in his 80s presented with a 3-week history of fatigue, unsteadiness and abdominal pain, and new findings of anaemia, kidney injury and hypercalcaemia. Laboratory evaluation, bone marrow biopsy and positron emission tomography/computed tomography (PET/CT) confirmed the diagnosis of splenic marginal zone lymphoma which produced calcitriol (1,25-(OH)D), causing the patient's hypercalcaemia.
恶性肿瘤相关性高钙血症（HCM）是一种副瘤综合征，常预示预后不良。我们报告了一例非常罕见的（<1%）HCM 病例，其病因是脾边缘区淋巴瘤产生的肾脏外 1,25-二羟维生素 D（1,25-(OH)D）。一名 80 多岁的男性因疲劳、不稳定和腹痛就诊，发现新的贫血、肾损伤和高钙血症。实验室检查、骨髓活检和正电子发射断层扫描/计算机断层扫描（PET/CT）证实了脾边缘区淋巴瘤的诊断，该肿瘤产生了 1,25-二羟维生素 D（1,25-(OH)D），导致患者高钙血症。
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