Vaitiekiene Audrone, Kulboke Migle, Bieseviciene Monika, Bartnykaite Agne, Kireilis Benas, Rinkuniene Diana, Jankauskas Antanas, Zemaitis Justinas, Gaidamavicius Ignas, Gerbutavicius Rolandas, Vaitiekus Domas, Vaskelyte Jolanta Justina, Sakalyte Gintare
Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
Department of Oncology and Hematology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
J Clin Med. 2024 Jan 29;13(3):773. doi: 10.3390/jcm13030773.
The hematopoietic stem cell transplantation (HSCT) process is known to cause cardiac toxicity of different grades. In this paper, we aimed to evaluate the impact of mobilization procedure of hematopoietic stem cells for autologous HSCT process for left and right ventricle sizes and functions. The data of 47 patients undergoing autologous HSCT were analyzed. All patients underwent hematopoietic stem cell mobilization with chemotherapy and filgrastim at 10 µg/kg/d. Echocardiography was performed two times: before enrolling in the transplantation process and after mobilization before the conditioning regimen for transplantation. Changes in left and right ventricle (RV) diameter and systolic and diastolic function of the left ventricle and systolic function of the RV were measured. : A statistically significant difference was observed in the change of right ventricular function (S')-it slightly decreased. Mean S' before mobilization was 13.93 ± 2.85 cm/s, and after mobilization it was 12.19 ± 2.64 cm/s ( = 0.003). No statistically significant change in left ventricular diameter and systolic and diastolic function and RV diameter was observed. : The mobilization procedure in patients undergoing autologous HSCT is associated with reduced RV systolic function. S' could be used as a reliable tool to evaluate early cardiotoxicity in HSCT patients and guide further follow-up.
已知造血干细胞移植（HSCT）过程会导致不同程度的心脏毒性。在本文中，我们旨在评估自体HSCT过程中造血干细胞动员程序对左右心室大小和功能的影响。分析了47例接受自体HSCT患者的数据。所有患者均采用化疗和10μg/kg/d的非格司亭进行造血干细胞动员。进行了两次超声心动图检查：在进入移植过程之前以及动员后、移植预处理方案之前。测量了左右心室（RV）直径、左心室收缩和舒张功能以及右心室收缩功能的变化。：观察到右心室功能变化（S'）有统计学意义的差异——它略有下降。动员前平均S'为13.93±2.85 cm/s，动员后为12.19±2.64 cm/s（P = 0.003）。未观察到左心室直径、收缩和舒张功能以及右心室直径有统计学意义的变化。：接受自体HSCT患者的动员程序与右心室收缩功能降低有关。S'可作为评估HSCT患者早期心脏毒性的可靠工具并指导进一步随访。
