3rd Department of Cardiology, Sotiria Thoracic Diseases General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Curr Pharm Des. 2024;30(7):485-488. doi: 10.2174/0113816128291822240131063712.
Atrial high-rate episodes (AHRE) are atrial tachyarrhythmias that are identified by the use of continuous rhythm monitoring devices such as pacemakers, defibrillators, or implantable cardiac monitors. Nevertheless, the therapeutic implications of these rhythm disturbances remain uncertain. The presence of AHRE is associated with an increased risk of stroke as compared to patients who do not exhibit AHRE. The utilisation of oral anticoagulation has the ability to mitigate the likelihood of stroke occurrence in patients with AHRE. However, it is important to note that this treatment approach is also linked to a severe bleeding rate of approximately 2% per year. The stroke rate among individuals diagnosed with AHRE appears to be comparatively lower when compared to patients diagnosed with atrial fibrillation. The efficacy and safety of anticoagulation in patients with AHRE have yet to be definitively established. Further research is required to provide a comprehensive understanding of the effectiveness and safety of oral anticoagulation in individuals with AHRE.
房性高频事件(AHRE)是由心脏起搏器、除颤器或植入式心脏监测器等连续节律监测设备识别的房性快速性心律失常。然而,这些节律紊乱的治疗意义仍然不确定。与没有房性高频事件的患者相比,AHRE 患者发生中风的风险增加。口服抗凝剂的使用可以降低 AHRE 患者中风发生的可能性。然而,需要注意的是,这种治疗方法也与每年约 2%的严重出血率有关。与诊断为心房颤动的患者相比,诊断为 AHRE 的患者的中风发生率似乎较低。AHRE 患者抗凝治疗的疗效和安全性尚未得到明确证实。需要进一步的研究来全面了解 AHRE 患者口服抗凝治疗的有效性和安全性。