ω-3脂肪酸补充剂对血液透析患者瘙痒的疗效。
Effectiveness of omega-3 fatty acid supplementation for pruritus in patients undergoing hemodialysis.
作者信息
Rafieipoor Alireza, Torkaman Mahdie, Azaryan Fatemeh, Tavakoli Aryan, Mohammadian Mohammad Keshavarz, Kohansal Atefeh, Shafaei Hanieh, Mirzaee Pouya, Motiee Bijarpasi Zeinab, Bahmani Parsa, Khosravi Masoud, Doaei Saeid, Gholamalizadeh Maryam
机构信息
Master of Nursing, Hormozgan University of Medical Sciences, Bandar Abbas, Hormozgan, Iran.
Department of Chemical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.
出版信息
Front Nutr. 2024 Jan 25;11:1328469. doi: 10.3389/fnut.2024.1328469. eCollection 2024.
BACKGROUND
Patients undergoing hemodialysis (HD) frequently experience the chronic kidney disease-associated pruritus (CKD-aP).
OBJECTIVE
The aim of this study was to investigate the effectiveness of omega-3 supplementation in the management of CKD-aP in patients undergoing hemodialysis.
METHODS
In this triple blind, randomized clinical trial, the effect of the omega-3 supplement on uremic CKD-aP was assessed in 112 chronic hemodialysis patients at Caspian Hemodialysis Center in Rasht, Iran. Patients were randomly divided into the intervention group receiving omega-3 supplements (3 g/day) and the control group receiving placebo containing MCT oil for 2 months.
RESULTS
Omega-3 supplementation had no effect on CKD-aP. The results did not change after adjusting for age and sex, additional adjustments for weight, height, physical activity, smoking, and alcohol use, additional adjustments for underlying diseases and weight, height, physical activity, smoking, and drinking alcohol, and further adjustments for underlying diseases and biochemical indices.
DISCUSSION
Omega-3 supplementation for 2 months had no effect on CKD-aP in patients with CKD. Further studies with longer duration are warranted.
CLINICAL TRIAL REGISTRATION
https://www.irct.ir/trial/66638, IRCT20151226025699N6.
背景
接受血液透析（HD）的患者经常经历慢性肾脏病相关瘙痒（CKD-aP）。
目的
本研究旨在探讨补充ω-3对接受血液透析患者CKD-aP管理的有效性。
方法
在这项三盲随机临床试验中，在伊朗拉什特的里海血液透析中心，对112例慢性血液透析患者评估了ω-3补充剂对尿毒症性CKD-aP的影响。患者被随机分为接受ω-3补充剂（3克/天）的干预组和接受含中链甘油三酯油安慰剂的对照组，为期2个月。
结果
补充ω-3对CKD-aP无影响。在对年龄和性别进行调整后、对体重、身高、身体活动、吸烟和饮酒进行额外调整后、对基础疾病以及体重、身高、身体活动、吸烟和饮酒进行额外调整后，以及对基础疾病和生化指标进行进一步调整后，结果均未改变。
讨论
补充ω-3两个月对CKD患者的CKD-aP无影响。有必要进行持续时间更长的进一步研究。
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