Garden Fellow, Royal College of Physicians, London, England.
Clin Toxicol (Phila). 2024 Jan;62(1):56-60. doi: 10.1080/15563650.2024.2309328. Epub 2024 Feb 13.
The death of Socrates in 399 BCE is described in Plato's dialogue, the Phaedo, written an unknown time afterwards from accounts by others.
Socrates' death has almost always been attributed to his drinking an extract of poison hemlock, despite apparent discrepancies between the clinical features described in classical translations of the Phaedo and general clinical experience of poisoning with the toxic alkaloids it contains.
Recent acute philological analysis of the original Greek text has resolved many of the discrepancies by showing that the terms used in the classical translations were misinterpretations of the clinical signs described. It is also likely that the unpleasant clinical effects, such as vomiting, abdominal pain, diarrhoea and muscle fasciculation commonly described in modern reports of poison hemlock poisoning, were not mentioned to present the death of Socrates in a way consistent with his philosophical ideals and those of his pupil Plato.
Seen in this way, the death of Socrates can be accepted as a limited case report of poisoning. Even after reaching that conclusion, intriguing scientific questions remain about the toxicity of the coniine alkaloids and the mechanisms of their effects.
公元前 399 年,苏格拉底之死被记载于柏拉图的对话录《斐多篇》中,该书创作于之后的未知时间,依据的是他人的叙述。
苏格拉底之死几乎总是归因于他喝下了毒芹草的提取物,尽管《斐多篇》中描述的临床特征与其中所含的有毒生物碱的一般临床中毒经验之间存在明显差异。
最近对希腊文原文的急性语言学分析通过显示古典翻译中使用的术语是对所描述的临床症状的错误解释,解决了许多差异。同样,不愉快的临床影响,如呕吐、腹痛、腹泻和肌肉抽搐,在现代毒芹草中毒报告中通常被描述,但并没有被提及,以使苏格拉底之死与他的哲学理想和他的学生柏拉图的哲学理想相一致。
从这个角度来看,苏格拉底之死可以被视为中毒的一个有限案例报告。即使得出了这样的结论,关于coniine 生物碱的毒性及其作用机制仍然存在有趣的科学问题。