Department of Pediatric Surgery, Radboud University Medical Centre-Amalia Children's Hospital, Geert Grooteplein Zuid 10, Postal box 9101, 6500 HB, Nijmegen, The Netherlands.
Department of Medical Imaging, Radboud University Medical Centre, Nijmegen, The Netherlands.
Sci Rep. 2024 Feb 13;14(1):3585. doi: 10.1038/s41598-024-54189-4.
Current diagnostics in Hirschsprung's disease are often challenging and invasive. This study aims to investigate whether surface electroenterography can non-invasively discern healthy subjects from subjects suffering from Hirschsprung's disease. Nine healthy subjects (seven children, two adults) and eleven subjects suffering from surgically untreated Hirschsprung's disease (nine children, two adults) underwent an electroenterography procedure. This procedure consisted of ultrasound-guided placement of surface electrodes on the abdomen covering all parts of the colon, fasting and two 20-min electroenterography measurements separated by a meal. The dominant frequency, magnitude and relative increase (pre- to postprandial) of colonic activity were compared between both groups. The results showed that in the pediatric group, no significant differences in dominant frequency, colonic activity and relative power increase were observed between controls and patients. The adult patients showed decreased colonic motility and relative power increase in the electrodes closest to the distal colon, both when compared to the same electrodes in controls and to the more proximal electrodes of themselves. To conclude, electroenterography measurements in young children is challenging, but the results in adults demonstrate that these measurements can possibly distinguish between controls and Hirschsprung's patients. Therefore, optimization of electroenterography measurements in young children is necessary.
目前对先天性巨结肠症的诊断往往具有挑战性且具侵袭性。本研究旨在探讨体表胃肠电图是否能无创地区分健康受试者和先天性巨结肠症患者。9 名健康受试者（7 名儿童，2 名成人）和 11 名未经手术治疗的先天性巨结肠症患者（9 名儿童，2 名成人）接受了胃肠电图检查。该过程包括在腹部超声引导下放置体表电极，覆盖结肠的所有部位，禁食，并在餐前和餐后各进行 20 分钟的胃肠电图测量。比较两组的结肠活动主导频率、幅度和相对增加（餐前至餐后）。结果表明，在儿科组中，对照组和患者组之间的主导频率、结肠活动和相对功率增加没有显著差异。与对照组相同电极和自身更近端电极相比，成年患者的远端结肠附近电极的结肠蠕动和相对功率增加减少。总之，对幼儿进行胃肠电图测量具有挑战性，但成人的结果表明，这些测量可能能够区分对照组和先天性巨结肠症患者。因此，有必要优化幼儿的胃肠电图测量。
