Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Seoul National University College of Medicine, Seoul, Korea.
Korean J Intern Med. 2024 Mar;39(2):283-294. doi: 10.3904/kjim.2023.389. Epub 2024 Feb 14.
BACKGROUND/AIMS: Epicardial adipose tissue (EAT) shares pathophysiological properties with other visceral fats and potentially triggers local inflammation. However, the association of EAT with cardiovascular disease (CVD) is still debatable. The study aimed to observe the changes and associations in EAT and risk factors over time, as well as to investigate whether EAT was associated with CVD.
A total of 762 participants from Seoul National University Hospital (SNUH) and SNUH Gangnam Center were included in this study. EAT was measured using coronary computed tomography angiography.
Baseline EAT level was positively associated with body mass index (BMI), calcium score, atherosclerotic cardiovascular disease (ASCVD) 10-year risk score, glucose, triglycerides (TG)/high-density lipoprotein (HDL), but not with total cholesterol, low-density lipoprotein (LDL). At follow-up, EAT levels increased in all groups, with low EAT groups demonstrating a significant increase in EAT per year. Change in EAT was associated with a change in BMI, TG/HDL, and glucose, while changes in LDL, calcium score, and ASCVD 10-year risk score were not associated. Although calcium score and ASCVD 10-year risk score were associated with CVD events, baseline information of EAT, baseline EAT/body surface area, or EAT change was not available.
Metabolic risks, e.g., BMI, TG/HDL, and glucose, were associated with EAT change per year, whereas classical CVD risks, e.g., LDL, calcium score, and ASCVD 10-year risk score, were not. The actual CVD event was not associated with EAT volume, warranting future studies combining qualitative assessments with quantitative ones.
背景/目的：心外膜脂肪组织（EAT）与其他内脏脂肪具有相同的病理生理学特性，并可能引发局部炎症。然而，EAT 与心血管疾病（CVD）的关联仍存在争议。本研究旨在观察 EAT 及其危险因素随时间的变化和关联，以及探讨 EAT 是否与 CVD 相关。
本研究共纳入了 762 名来自首尔国立大学医院（SNUH）和 SNUH 江南中心的参与者。使用冠状动脉计算机断层血管造影术测量 EAT。
基线 EAT 水平与体重指数（BMI）、钙评分、动脉粥样硬化性心血管疾病（ASCVD）10 年风险评分、血糖、甘油三酯（TG）/高密度脂蛋白（HDL）呈正相关，但与总胆固醇、低密度脂蛋白（LDL）无关。在随访期间，所有组的 EAT 水平均增加，低 EAT 组的 EAT 每年显著增加。EAT 的变化与 BMI、TG/HDL 和血糖的变化相关，而 LDL、钙评分和 ASCVD 10 年风险评分的变化与 EAT 无关。尽管钙评分和 ASCVD 10 年风险评分与 CVD 事件相关，但基线 EAT、基线 EAT/体表面积或 EAT 变化的信息不可用。
代谢风险，如 BMI、TG/HDL 和血糖，与每年 EAT 的变化相关，而经典的 CVD 风险，如 LDL、钙评分和 ASCVD 10 年风险评分，与 EAT 的变化无关。实际的 CVD 事件与 EAT 体积无关，需要未来的研究将定性评估与定量评估相结合。
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