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多发性胸段髓内神经鞘瘤:一例报告

Multiple thoracic intramedullary schwannoma: A case report.

作者信息

Adji Novan Krisno, Putri Komang Yunita Wiryaning, Indreswari Laksmi, Gunawan Rudy, Nugraha Muhammad Yuda

机构信息

Department of Neurosurgery, Soebandi Regional Hospital, Jember, Indonesia; Faculty of Medicine, University of Jember, Indonesia.

Department of Neurology, Soebandi Regional Hospital, Jember, Indonesia; Faculty of Medicine, University of Jember, Indonesia.

出版信息

Int J Surg Case Rep. 2024 Mar;116:109330. doi: 10.1016/j.ijscr.2024.109330. Epub 2024 Feb 1.

Abstract

INTRODUCTION AND IMPORTANCE

Schwannoma's are benign but clinically progressive tumours. Mostly, they present as intradural extramedullary and as a single lesion. They are quite rare in the intramedullary region and multiple lesions. We report a rare case of Multiple Intramedullary Schwannoma in the thoracic region. The aim of this study to inform an uncommon case of intramedullary schwannoma and support an appropriate preoperative diagnostic.

CLINICAL PRESENTATION

A 43-year-old female patient was admitted with gradual onset weakness of both lower limbs (4/2) for last two months. Magnetic resonance imaging (MRI) scan disclosed an intramedullary tumour at the thoracal 11th and 12th vertebral levels. It measured 30x20x15 mm and 20x20x12 mm. Complete total resection of multiple lesions was done. Schwanoma's was confirmed based on the histopathological finding. The patient was discharged on 4th day post operative with both leg power 5/5 and needed to medical rehabilitation. Follow-up examination 1 months after surgery revealed favourable, neurological condition (modified McCormick scale: grade I).

CLINICAL DISCUSSION

Intramedullary schwannoma is often misdiagnosed as other types of intramedullary tumour. Schwannomas are usually benign and have well defined cleavage plane. Total resection achievable in most cases, offers the best clinical outcome and avoids subsequent recurrence.

CONCLUSION

Preoperative diagnosis of intramedullary schwannoma will help establish the optimum medical and surgical treatment and the prognosis. Timely surgery before permanent neurological deficit and gross total resection is recommended to achieve good clinical outcome.

摘要

引言与重要性

施万细胞瘤是良性但临床上呈进行性发展的肿瘤。大多数情况下,它们表现为硬脊膜内髓外单发病变。在髓内区域和多发病变中相当罕见。我们报告一例罕见的胸段多发性髓内施万细胞瘤病例。本研究旨在介绍髓内施万细胞瘤这一罕见病例,并支持进行适当的术前诊断。

临床表现

一名43岁女性患者因近两个月双下肢逐渐出现无力(4/2级)入院。磁共振成像(MRI)扫描显示在第11和12胸椎水平有一个髓内肿瘤。其大小为30×20×15毫米和20×20×12毫米。对多个病灶进行了完整的全切除。根据组织病理学检查结果确诊为施万细胞瘤。患者术后第4天出院,双下肢肌力5/5,需要进行医学康复治疗。术后1个月的随访检查显示神经状况良好(改良 McCormick 分级:I级)。

临床讨论

髓内施万细胞瘤常被误诊为其他类型的髓内肿瘤。施万细胞瘤通常为良性,具有清晰的分离平面。大多数情况下可实现全切除,能带来最佳临床效果并避免后续复发。

结论

髓内施万细胞瘤的术前诊断有助于确定最佳的药物和手术治疗方案以及预后。建议在出现永久性神经功能缺损之前及时手术并进行全切除,以获得良好的临床效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bdc/10943640/1bc8a402a054/gr1.jpg

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