From the Public Organization for Providing Health Care Services, Regional Department of North and East Greece, Thessaloniki, Greece (E.F.); Faculty of Nursing, Center for Health Services Management and Evaluation, National and Kapodistrian University of Athens, Athens, Greece (P.G.); Department of Agricultural Economics and Rural Development, Agricultural University of Athens, Athens, Greece (K.C., C.M.); and Laboratory of Pesticide Science, Department of Crop Science, Agricultural University of Athens, Athens, Greece (E.K.).
J Occup Environ Med. 2024 May 1;66(5):e176-e184. doi: 10.1097/JOM.0000000000003068. Epub 2024 Feb 14.
The objective of this study was to evaluate the relationship between pesticide exposure and depression.
A cross-sectional study was performed in a study population of 252 Greek male farmers using the Center for Epidemiological Studies Depression scale. Cumulative pesticide exposure was categorized in three mutually exclusive groups related to lifetime pesticide use: low (<275 days, the reference group), intermediate (276 to 1200 days), and high (>1200 days). Acute pesticide exposure was categorized in pesticide poisoning events and high pesticide exposure events. Multivariable logistic regression analysis was performed, and odds ratios, 95% confidence intervals, and P values were presented.
After adjusting for confounding factors, a positive significant association was found between both high-exposure group and high pesticide exposure events and depressive symptoms.
Apart from acute, high cumulative pesticide exposure may as well contribute to the development of depression.
本研究旨在评估农药暴露与抑郁之间的关系。
采用横断面研究方法，对 252 名希腊男性农民进行研究，使用流行病学研究中心抑郁量表评估抑郁症状。累积农药暴露分为三组，分别为低暴露组（<275 天，参照组）、中暴露组（276-1200 天）和高暴露组（>1200 天）。急性农药暴露分为农药中毒事件和高农药暴露事件。采用多变量逻辑回归分析，给出比值比、95%置信区间和 P 值。
调整混杂因素后，高暴露组和高农药暴露事件与抑郁症状呈正相关。
除了急性暴露外，高累积农药暴露也可能导致抑郁的发生。
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