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一例因推测局部眼部接种导致全身使用格隆溴铵引起的药物性瞳孔不等大病例。

A Case of Pharmacologic Anisocoria in Systemic Glycopyrrolate Use from Presumed Local Ocular Inoculation.

作者信息

Adamkiewicz Daniel, Magazin Maja, Thomas Dilip

机构信息

Department of Ophthalmology, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.

出版信息

Neuroophthalmology. 2024 Feb 12;48(1):41-45. doi: 10.1080/01658107.2023.2273473. eCollection 2024.

Abstract

Anisocoria is a common finding in ophthalmic clinical practice. History taking and examination is critical in appropriately diagnosing and managing anisocoria, as the differential can be extensive ranging from benign to life-threatening entities. This case discusses the presentation of a 22-year-old female with a history of myopia and hyperhidrosis who presented with pharmacologic anisocoria which was presumed to be from inadvertent topical exposure to conventional glycopyrrolate tablets. To our knowledge, pharmacologic mydriasis from exposure to residue from conventional glycopyrrolate tablets has not been reported in the English literature. This case highlights the importance of medication and contact lens handling with anticholinergic agents.

摘要

瞳孔不等大是眼科临床实践中的常见表现。病史采集和检查对于准确诊断和处理瞳孔不等大至关重要,因为鉴别诊断范围广泛,从良性情况到危及生命的疾病都有可能。本病例讨论了一名22岁近视和多汗症女性患者,其出现药物性瞳孔不等大,推测是由于不经意间局部接触了传统甘罗溴铵片。据我们所知,英文文献中尚未报道因接触传统甘罗溴铵片残留而导致的药物性散瞳。本病例强调了使用抗胆碱能药物时药物和隐形眼镜处理的重要性。

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本文引用的文献

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Pharmacologic Mydriasis Secondary to Topical Glycopyrronium Tosylate Cloths: Clinical Characterization From a Multicenter Analysis.
J Neuroophthalmol. 2022 Dec 1;42(4):530-534. doi: 10.1097/WNO.0000000000001567. Epub 2022 Mar 24.
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Reversible anisocoria due to inadvertent ocular exposure to topical anticholinergic treatment for primary axillary hyperhidrosis.
Can J Ophthalmol. 2019 Dec;54(6):e300-e302. doi: 10.1016/j.jcjo.2019.04.009. Epub 2019 Jun 4.
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Pharmacologic anisocoria due to nebulized ipratropium bromide: A diagnostic challenge.
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