Al Saeghi Shadya, Al-Mahrouqi Tamadhir, Al-Khadhuri Maha, Al-Ghabshi Rahma, Al-Sabti Jokha, Jose Sachin, Gowri Vaidyanathan
Obstetrics and Gynecology Residency Training Program, Oman Medical Specialty Board, Muscat, Oman.
General Foundation Program, Oman Medical Specialty Board, Muscat, Oman.
Int J Reprod Biomed. 2024 Jan 25;21(12):1013-1020. doi: 10.18502/ijrm.v21i12.15039. eCollection 2023 Dec.
Infertility affects around 10-15% of couples worldwide and is both a social and medical problem. Parental consanguinity is considered to reduce fertility reserve. Consanguineous marriages, especially first cousin marriages, are very common in Oman according to the Oman National Health Survey data.
This study aimed to determine whether women born to consanguineous parents have reduced ovarian reserve.
This cohort study was conducted on 414 women aged 39, treated for infertility at Sultan Qaboos University hospital and Royal hospital, Muscat, Oman from January 2019-December 2020. Each participant was interviewed and a complete history, including parental consanguinity and physical examination, were recorded. On day 2 of the menstrual cycle, serum concentration of the following was performed: follicle-stimulating hormone (FSH), luteinizing hormone, estradiol, prolactin, thyroid stimulating hormone, and anti-Müllerian hormone (AMH). AMH was done, if necessary, on other days of the cycle. Antral follicle count (AFC) was done on day 2 and 3 of the menstrual cycle.
Of the 414 women, parental consanguinity was present in 40.2% of couples. In women with low AFC, parental consanguinity was present in 15.3% compared to 13.0% in the non-consanguineous group. About 15% of women with low AMH had consanguineous parents, compared to 20.2% from the non-consanguineous group. High levels of FSH were present in 6.5% and 4.2% of the consanguineous and non-consanguineous groups, respectively. No significant difference was observed in AFC with reference to body mass index.
The results from this study showed no statistically significant difference in low ovarian reserves (AFC, AMH, and FSH) in women whose parents had a consanguineous marriage.
不孕症影响着全球约10%-15%的夫妇，是一个社会和医学问题。父母近亲结婚被认为会降低生育储备。根据阿曼国家健康调查数据，近亲婚姻，尤其是表亲婚姻，在阿曼非常普遍。
本研究旨在确定近亲结婚父母所生的女性卵巢储备是否降低。
本队列研究对2019年1月至2020年12月在阿曼马斯喀特苏丹卡布斯大学医院和皇家医院接受不孕症治疗的414名39岁女性进行。对每位参与者进行访谈，并记录包括父母近亲结婚情况和体格检查在内的完整病史。在月经周期的第2天，检测以下血清浓度：促卵泡生成素（FSH）、黄体生成素、雌二醇、催乳素、促甲状腺激素和抗苗勒管激素（AMH）。如有必要，在月经周期的其他时间检测AMH。在月经周期的第2天和第3天进行窦卵泡计数（AFC）。
在414名女性中，40.2%的夫妇存在父母近亲结婚情况。在AFC低的女性中，15.3%存在父母近亲结婚，非近亲组为13.0%。AMH低的女性中约15%有近亲结婚的父母，非近亲组为20.2%。近亲组和非近亲组中FSH水平高的分别占6.5%和4.2%。AFC与体重指数之间未观察到显著差异。
本研究结果显示，父母近亲结婚的女性在低卵巢储备（AFC、AMH和FSH）方面无统计学显著差异。
