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糖尿病患者中由[具体病因未给出]引起的脊柱感染:一例病例报告及文献综述

Spinal infection caused by in a diabetic: a case report and literature review.

作者信息

Li Hongtao, Pan Hongyu, Lei Yang, Wang Haozhong, Li Sen, Xiao Changming

机构信息

Department of Spinal Surgery, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China.

Division of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

出版信息

Front Med (Lausanne). 2024 Feb 2;11:1348203. doi: 10.3389/fmed.2024.1348203. eCollection 2024.

Abstract

Spinal infections, notably those induced by (), represent a complex and uncommon clinical challenge. In individuals with diabetes mellitus, the risk is exacerbated due to a compromised immune response and a heightened vulnerability to non-standard pathogens. This case report chronicles the intricate diagnostic and treatment journey of a 59-year-old diabetic patient grappling with a spinal infection attributed to . The diagnosis was delayed due to non-specific symptoms and unclear radiological signs. The administration of voriconazole, a targeted antifungal treatment, resulted in a significant clinical and radiological improvement, underscoring its effectiveness in treating such unusual fungal spinal infections; meanwhile, we found that terbinafine hydrochloride also has a similar effect in treating fungal spinal infections. This case underscores the importance of considering fungal causes in spinal infections among diabetic patients and highlights prompt diagnosis and individualized targeted antifungal therapy.

摘要

脊柱感染,尤其是由()引起的感染,是一项复杂且罕见的临床挑战。在糖尿病患者中,由于免疫反应受损以及对非标准病原体的易感性增加,风险会进一步加剧。本病例报告记录了一名59岁糖尿病患者因()引发脊柱感染的复杂诊断和治疗过程。由于症状不特异且放射学征象不明确,诊断有所延迟。伏立康唑作为一种靶向抗真菌治疗药物,其应用带来了显著的临床和放射学改善,突显了其在治疗此类罕见真菌性脊柱感染中的有效性;同时,我们发现盐酸特比萘芬在治疗真菌性脊柱感染方面也有类似效果。该病例强调了在糖尿病患者的脊柱感染中考虑真菌病因的重要性,并突出了及时诊断和个体化靶向抗真菌治疗的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82c8/10869514/20820b0a9485/fmed-11-1348203-g001.jpg

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