在有大量输血风险的创伤患者中，使用四因子凝血酶原复合物浓缩剂会加剧凝血酶生成：PROCOAG试验的一项辅助研究。 - Suppr

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超能文献

The administration of four-factor prothrombin complex concentrate exacerbates thrombin generation in trauma patients at risk of massive transfusion: an ancillary study of the PROCOAG trial.

作者信息

Greze Jules, Marlu Raphael, Baud Mariette, Seyve Landry, Gauss Tobias, Bouzat Pierre

机构信息

Inserm, U1216, CHU Grenoble Alpes, Grenoble Institute Neurosciences, Univ. Grenoble Alpes, 38000, Grenoble, France.

CNRS UMR5525 TIMC, Hemostasis Laboratory, CHU Grenoble Alpes, Univ. Grenoble Alpes, 38000, Grenoble, France.

出版信息

Crit Care. 2024 Feb 19;28(1):51. doi: 10.1186/s13054-024-04836-z.

DOI:10.1186/s13054-024-04836-z

PMID:38374057

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10875840/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a16e/10875840/39c0ea0f971b/13054_2024_4836_Fig1_HTML.jpg

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本文引用的文献

Efficacy and Safety of Early Administration of 4-Factor Prothrombin Complex Concentrate in Patients With Trauma at Risk of Massive Transfusion: The PROCOAG Randomized Clinical Trial.

JAMA. 2023 Apr 25;329(16):1367-1375. doi: 10.1001/jama.2023.4080.

The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition.

Crit Care. 2023 Mar 1;27(1):80. doi: 10.1186/s13054-023-04327-7.

Effects of tranexamic acid on coagulofibrinolytic markers during the early stage of severe trauma: A propensity score-matched analysis.

Medicine (Baltimore). 2022 Aug 12;101(32):e29711. doi: 10.1097/MD.0000000000029711.

Endogenous thrombin potential following hemostatic therapy with 4-factor prothrombin complex concentrate: a 7-day observational study of trauma patients.

Crit Care. 2014 Jul 9;18(4):R147. doi: 10.1186/cc13982.

Early prediction of massive transfusion in trauma: simple as ABC (assessment of blood consumption)?

J Trauma. 2009 Feb;66(2):346-52. doi: 10.1097/TA.0b013e3181961c35.

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