Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Eur Rev Med Pharmacol Sci. 2024 Feb;28(3):1194-1201. doi: 10.26355/eurrev_202402_35358.
This study aimed to investigate the association between serum galanin (GAL) and neuron-specific enolase (NSE) levels in children with convulsive status epilepticus (CSE) and their relationship with abnormal electroencephalogram (EEG) patterns. Additionally, the study assessed the effectiveness of a combination therapy involving midazolam, diazepam, and phenobarbital in treating CSE.
The research involved 100 children diagnosed with CSE and included a control group of 50 healthy children. Serum GAL and NSE levels were measured, and EEGs were analyzed for abnormalities in the CSE group. Comparisons were made between the healthy control group and the CSE group, particularly within the first 24 hours after persistent seizures. The severity of EEG abnormalities was correlated with GAL and NSE levels. The treatment consisted of an observation group that received the triple therapy of midazolam, diazepam, and phenobarbital, while a control group received diazepam and phenobarbital. Clinical efficacy, symptom improvement, Status Epilepticus Severity Score (STESS), and adverse reactions were evaluated.
The results indicated elevated levels of GAL and NSE in the CSE group, with higher levels noted within 24 hours after persistent seizures. Furthermore, a positive correlation was observed between the severity of EEG abnormalities and GAL and NSE levels. The group receiving the triple therapy demonstrated superior efficacy, faster resolution of seizures and fever, reduced STESS scores, and fewer adverse reactions than the control group. In conclusion, this study highlights the positive correlation between serum GAL and NSE levels and the severity of EEG abnormalities in pediatric CSE. The triple therapy approach is effective in treating CSE, leading to improved clinical symptoms, reduced brain damage, and enhanced safety.
The study concludes that serum GAL and NSE levels in children with convulsive status epilepticus are positively correlated with the degree of EEG abnormalities. The combination therapy involving midazolam, diazepam, and phenobarbital is effective in treating children with convulsive status epilepticus, significantly improving clinical symptoms, reducing brain damage, and ensuring safety.
本研究旨在探讨惊厥性癫痫持续状态（CSE）患儿血清甘丙肽（GAL）和神经元特异性烯醇化酶（NSE）水平的相关性及其与异常脑电图（EEG）模式的关系。此外，还评估了咪达唑仑、地西泮和苯巴比妥联合治疗 CSE 的效果。
研究纳入了 100 例确诊为 CSE 的患儿，并设置了 50 例健康儿童的对照组。测量血清 GAL 和 NSE 水平，并分析 CSE 组的 EEG 异常。比较健康对照组和 CSE 组，特别是在持续性癫痫发作后 24 小时内的差异。还将 GAL 和 NSE 水平与 EEG 异常的严重程度进行了相关性分析。治疗组接受咪达唑仑、地西泮和苯巴比妥的三联疗法，对照组则接受地西泮和苯巴比妥。评估了临床疗效、症状改善、癫痫持续状态严重程度评分（STESS）和不良反应。
结果表明，CSE 组 GAL 和 NSE 水平升高，且在持续性癫痫发作后 24 小时内水平更高。此外，还观察到 EEG 异常严重程度与 GAL 和 NSE 水平之间存在正相关。与对照组相比，三联疗法组的疗效更优，癫痫发作和发热更快缓解，STESS 评分更低，不良反应更少。总之，本研究强调了血清 GAL 和 NSE 水平与儿科 CSE 患者 EEG 异常严重程度之间的正相关性。咪达唑仑、地西泮和苯巴比妥的联合治疗方案对治疗 CSE 有效，可改善临床症状，减少脑损伤，提高安全性。
研究表明，惊厥性癫痫持续状态患儿的血清甘丙肽（GAL）和神经元特异性烯醇化酶（NSE）水平与脑电图（EEG）异常程度呈正相关。咪达唑仑、地西泮和苯巴比妥联合治疗惊厥性癫痫持续状态的疗效显著，能明显改善临床症状，减轻脑损伤，确保安全性。
