Wang Kaixin, Huang Shiqian, Fu Daan, Yang Xinxin, Ma Lulin, Zhang Tianhao, Zhao Wenjing, Deng Daling, Ding Yuanyuan, Zhang Yanyan, Huang Li, Chen Xiangdong
Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
CNS Neurosci Ther. 2024 Feb;30(2):e14536. doi: 10.1111/cns.14536.
Depression is a prevalent psychiatric disorder with high long-term morbidities, recurrences, and mortalities. Despite extensive research efforts spanning decades, the cellular and molecular mechanisms of depression remain largely unknown. What's more, about one third of patients do not have effective anti-depressant therapies, so there is an urgent need to uncover more mechanisms to guide the development of novel therapeutic strategies. Adenosine triphosphate (ATP) plays an important role in maintaining ion gradients essential for neuronal activities, as well as in the transport and release of neurotransmitters. Additionally, ATP could also participate in signaling pathways following the activation of postsynaptic receptors. By searching the website PubMed for articles about "ATP and depression" especially focusing on the role of extracellular ATP (eATP) in depression in the last 5 years, we found that numerous studies have implied that the insufficient ATP release from astrocytes could lead to depression and exogenous supply of eATP or endogenously stimulating the release of ATP from astrocytes could alleviate depression, highlighting the potential therapeutic role of eATP in alleviating depression.
Currently, there are few reviews discussing the relationship between eATP and depression. Therefore, the aim of our review is to conclude the role of eATP in depression, especially focusing on the evidence and mechanisms of eATP in alleviating depression.
We will provide insights into the prospects of leveraging eATP as a novel avenue for the treatment of depression.
抑郁症是一种常见的精神疾病，具有较高的长期发病率、复发率和死亡率。尽管经过了数十年的广泛研究，但抑郁症的细胞和分子机制仍 largely 未知。此外，约三分之一的患者没有有效的抗抑郁治疗方法，因此迫切需要揭示更多机制以指导新型治疗策略的开发。三磷酸腺苷（ATP）在维持神经元活动所必需的离子梯度以及神经递质的运输和释放中起着重要作用。此外，ATP 还可在突触后受体激活后参与信号通路。通过在网站 PubMed 上搜索过去 5 年中关于“ATP 与抑郁症”的文章，特别是关注细胞外 ATP（eATP）在抑郁症中的作用，我们发现大量研究表明星形胶质细胞释放的 ATP 不足可能导致抑郁症，而外源性供应 eATP 或内源性刺激星形胶质细胞释放 ATP 可缓解抑郁症，这突出了 eATP 在缓解抑郁症方面的潜在治疗作用。
目前，很少有综述讨论 eATP 与抑郁症之间的关系。因此，我们综述的目的是总结 eATP 在抑郁症中的作用，特别是关注 eATP 缓解抑郁症的证据和机制。
我们将深入探讨利用 eATP 作为治疗抑郁症新途径的前景。
