2022 年在刚果民主共和国南基伍省检测到恶性疟原虫中的青蒿素耐药标记物 Kelch-13 469Y。
Detection of Artemisinin Resistance Marker Kelch-13 469Y in Plasmodium falciparum, South Kivu, Democratic Republic of the Congo, 2022.
机构信息
Institute of International Health, Center for Global Health, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Center for Tropical Diseases & Global Health, Université Catholique de Bukavu, Bukavu, Democratic Republic of the Congo.
出版信息
Am J Trop Med Hyg. 2024 Feb 20;110(4):653-655. doi: 10.4269/ajtmh.23-0740. Print 2024 Apr 3.
Partial artemisinin resistance has emerged in East Africa, posing a threat to malaria control across the continent. The Democratic Republic of the Congo carries one of the heaviest malaria burdens globally, and the South Kivu province directly borders current artemisinin resistance hot spots, but indications of such resistance have not been observed so far. We assessed molecular markers of antimalarial drug resistance in 256 Plasmodium falciparum isolates collected in 2022 in South Kivu, Democratic Republic of the Congo. One isolate carried the P. falciparum Kelch-13 469Y variant, a marker associated with partial artemisinin resistance and decreased lumefantrine susceptibility in Uganda. In addition, the multidrug resistance-1 mutation pattern suggested increased lumefantrine tolerance.
东非已经出现青蒿素部分耐药性，这对整个非洲大陆的疟疾防控构成威胁。刚果民主共和国是全球疟疾负担最重的国家之一，南基伍省与当前青蒿素耐药热点地区直接接壤，但迄今尚未发现存在此类耐药性的迹象。我们评估了 2022 年在刚果民主共和国南基伍采集的 256 株疟原虫分离株中的抗疟药物耐药性分子标记。一个分离株携带疟原虫 Kelch-13 469Y 突变，该突变与在乌干达青蒿素部分耐药性和降低本芴醇敏感性有关。此外，多药耐药-1 突变模式表明本芴醇耐药性增加。
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