心肌肌球蛋白的钙调蛋白依赖性磷酸化

The calmodulin-dependent phosphorylation of cardiac myosin.

作者信息

Hofmann F, Zimmer M

出版信息

Adv Myocardiol. 1985;5:87-95. doi: 10.1007/978-1-4757-1287-2_6.

Abstract

Cardiac myosin light chains are phosphorylated in vivo and in vitro. The enzyme myosin light-chain kinase, has been purified and found to be very specific for cardiac myosin light chains. Experiments with skinned cardiac fibers suggest that phosphorylation of myosin light chain-2-decreases ATP consumption, presumably by lowering the cross-bridge cycle. These results are discussed in this chapter.

摘要

心肌肌球蛋白轻链在体内和体外均可被磷酸化。肌球蛋白轻链激酶已被纯化，且发现其对心肌肌球蛋白轻链具有高度特异性。对去表皮心肌纤维的实验表明，肌球蛋白轻链-2的磷酸化可能通过降低横桥循环来减少ATP消耗。本章将对这些结果进行讨论。